CompletedPhase 4ACTRN12617001498381

Use of antibiotic prophylaxis in the prevention of postoperative infection of third impacted mandibular molars

Antibiotic Prophylaxis in the prevention of infectious complications in mandibular impacted third molars extraction: A randomized clinical trial


Sponsor

Facultad de Odontología. Universidad de Chile

Enrollment

120 participants

Start Date

May 2, 2016

Study Type

Interventional

Conditions

Summary

Third molar surgery is the most frequent procedure in oral and maxillofacial surgery. Surgical wound infection is the most prevalent complication. Determine if the use of 2 gr. of Amoxicillin as AP reduces the proportion of postoperative infectious complications in the impacted third molar extraction compared to placebo. To determine the proportion of postoperative infectious complications of the experimental group (2 gr Amoxicillin) and control group (placebo) derived from the exodoncia of impacted mandibular third molars. To compare the proportion of postoperative infectious complications of the experimental group versus the control group. To compare the proportion of rescue medication requirement associated with postoperative pain between the experimental group versus the control group. Describe any adverse reactions resulting from the use of 2 gr. Amoxicillin as AP.


Eligibility

Sex: Both males and femalesMin Age: 15 YearssMax Age: 35 Yearss

Inclusion Criteria1

  • Healthy patients between 15 to 35 years old: Clinically and radiographically presence at least of one impacted mandibular third molar,

Exclusion Criteria9

  • Pregnancy.
  • Allergy to penicillin and its derivatives.
  • Allergy to nonsteroidal anti-inflammatory drugs.
  • Patients with gastric ulcer.
  • Patients who have undergone any type of antibiotic treatment at least 30 days before surgery.
  • Patients with pericoronaritis episode up to 7 days before the intervention.
  • Patients with psychiatric illness.
  • Immunocompromised
  • Patients with addiction to narcotic drugs or illicit substances

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Interventions

2 gr. Amoxicillin one hour before the surgery . Oral tablet

2 gr. Amoxicillin one hour before the surgery . Oral tablet


Locations(1)

Santiago, Chile

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ACTRN12617001498381