CompletedPhase 4ACTRN12618000115235

The effects of Caffeine on Attentional Networks

The effects of Caffeine on Attentional Networks in Healthy Volunteers


Sponsor

University of Tasmania

Enrollment

24 participants

Start Date

May 16, 2018

Study Type

Interventional

Conditions

Summary

This study will will address the gaps in the literature by exploring the underlying neural correlates of an acute dose of caffeine using both an attentional network task and a flanker Go/NoGo task. Specifically, caffeine is expected to improve the alerting and executive control networks of attention, but not the orienting network. For the attentional network task, it is hypothesised there will be a reduction in reaction time and an increase brain activity (N1 amplitude) following alerting (central) but not orienting (spatial) cues after caffeine ingestion in comparison to placebo. For the flanker go/nogo task, it is hypothesised that Reaction Time and brain activity (N2 amplitude) will be greater for incongruent relative to congruent trials, and that this flanker interference effect would be reduced from pre- to post-ingestion for caffeine relative to placebo.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 35 Yearss

Inclusion Criteria1

  • Participation will be restricted to low caffeine users (less than 100mg per day) as assessed by the Caffeine and energy drink questionnaire.

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Interventions

Acute (1 day) oral ingestion of 200mg Caffeine (2 x capsules) with a one-week washout period. Adherence monitored via direct observation by study staff.

Acute (1 day) oral ingestion of 200mg Caffeine (2 x capsules) with a one-week washout period. Adherence monitored via direct observation by study staff.


Locations(1)

TAS, Australia

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ACTRN12618000115235