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RecruitingACTRN12618000186257

Proton Density Fat Fraction MRI to estimate liver iron content

Comparing estimation of liver iron load between Ferriscan(TM) and Proton Density Fat Fraction (PDFF) by magnetic resonance imaging, in patients with hyperferritinaemia

Sponsor

The Canberra Hospital

Enrollment

40 participants

Start Date

Sep 7, 2017

Study Type

Interventional

Conditions

alcoholic fatty liver diseasehereditary haemochromatosisdisorders of red cell metabolismacquired iron overload

Summary

This project aims to evaluate the results of a relatively inexpensive, noninvasive Liver MRI using an algorithm called “Proton Density Fat Fraction MRI (PDFF)” which uses “multi-peak spectral modelling and R2*”, and compare them against an alternative, more expensive technology called “Liver Ferriscan®” (Resonance Health, Western Australia), which is accepted as a reference standard for determining liver iron content.

Eligibility

Sex: Both males and females

Inclusion Criteria1

  • Elevated serum ferritin level > 500ug/L (as repeated a second time by a central diagnostic laboratory after 4 weeks)

Exclusion Criteria3

  • Clinically relevant investigations to explore alternative causes for hyperferritinaemia pending (e.g. chronic infection, malignancy etc when clinically deemed appropriate)
  • Any contraindication to MRI scanning including claustrophobia, and incompatible indwelling metallic implants
  • Terminal illness with a life expectancy less than 3 months
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Interventions

Blood testing, as routinely already performed, may need to be repeated at ACT Pathology to confirm through a centralised technique, the magnitude of hyperferritinaemia. No other additional blood tests

Blood testing, as routinely already performed, may need to be repeated at ACT Pathology to confirm through a centralised technique, the magnitude of hyperferritinaemia. No other additional blood tests are required for participating in this study, however the treating doctor may have already recommended additional tests in order to try to investigate the hyperferritinaemia. Any relevant data here may be collected by the study investigators. MRI scanning involves a single presentation to the radiology facility where both the Ferriscan(TM) and the PDFF scan will be performed. In total this takes approximtely 20 minutes. The MRI technologist will perform this procedure for you. The results of the MRI scans will be forwarded to your treating doctor who will then discuss these results with you.

Locations(1)

The Canberra Hospital - Garran

ACT,NSW, Australia

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ACTRN12618000186257