A comparative study looking at the prevalence of human papilloma virus (HPV) and HPV types in term and preterm labour cases by testing placentae, high vaginal swabs and maternal blood (cfDNA) (HIPPOP trial).

This study is investigating whether a virus called human papillomavirus (HPV) found in the placenta might play a role in causing premature birth. Premature birth is a major cause of newborn illness and death. Researchers will test placentas, vaginal swabs, and blood samples from women who go into labour early (preterm) and compare them with women who deliver at term. If HPV is linked to preterm birth, it may be possible in the future to screen for it and develop treatments to prevent premature labour. You may be eligible if: - You are a pregnant woman aged 18 or older - You are in labour or threatened labour at any time in your second or third trimester - You are being induced at term for routine reasons (e.g. post-dates, social reasons) - You have a history of preterm birth or shortened cervix You may NOT be eligible if: - You are under 18 years old - You are being induced or having an emergency caesarean due to concerns about your baby or your own health (e.g. growth restriction, pre-eclampsia) - You are having an elective (planned) caesarean section - You are carrying twins or more, or have a known uterine abnormality Talk to your doctor about whether this trial might be right for you.