Evaluation of ocular signs and symptoms following contact lens wear

In this double masked, contralateral design study, participants will be administered (by a final year optometry student) with hydrogel or silicone hydrogel lenses soaked in either one of the 3 different contact lens care solutions; Biotrue, RevitaLens OcuTec and Opti-free PureMoist. All the contact lens and lens care solutions are available in the Australian market for use. Following soaking for either 1, 10 or 30 days, the lenses will be worn by one eye of the human participants. The other eye will wear a lens of the same material that was soaked in sterile buffered saline solution (control). Both the lenses will look same, neither the participant nor examiner (Stage 5 optometry student under guidance of qualified optometrist) will know which eye is allocated for the control/MPS-soaked lens. The lens allocation will be assigned by a clinical research coordinator. The lens will remain in the participant’s eye for 2 hours, after which visual acuity will be measured and ocular signs and symptoms evaluated using slit lamp biomicroscopy, Oculus Keratograph and Lipiview imaging instruments. Each participant is expected to be evaluated at 9 different visits, for 3 different MPS solutions at 3 different time points of lens-solution soaking with at least 48 hours washout period in between visits. Participants will receive same type of lens for every visit.