A randomised double-blind placebo controlled trial of cardiovascular risk reduction during bereavement

Exclusion Criteria2

• Active malignancy or any severe illness, respiratory, heart, liver, renal failure, coagulopathy, thrombocytopenia, cognitive impairment, psychotic illness, immunosuppressive illness or taking immunosuppressive drugs, nursing home residents or cannot speak or read English. We will further exclude people taking beta blockers, heart rate lowering calcium channel blockers, aspirin or with resting systolic BP<120mmHg or heart rate <60bpm, or with contraindication to aspirin or beta blockers, including peptic ulcer, asthma, unstable diabetes mellitus, or known allergy to these drugs.
• Withdrawal: Subjects will be withdrawn at the project investigator's discretion, including if it is considered that participatiing in the study is causing undue psychological distress, or at the subjects request.