RecruitingPhase 4ACTRN12618001600235

Does the medication 'tranexamic acid' decrease pain and improve function in the short term after arthroscopic meniscectomy?


Sponsor

Prof Gary Hooper

Enrollment

40 participants

Start Date

Apr 20, 2018

Study Type

Interventional

Conditions

Summary

The aim of this pilot study is assess the efficacy of tranexamic acid in reducing post-operative pain, swelling and range of motion in patients undergoing arthroscopic meniscectomies. It is a blinded study in which participants are randomised to receive one intraoperative dose of either intravenous tranexamic acid or placebo (saline). Data collected is as follows: pain (0-10 scale), Lysholm knee score and Tegener activity score (to assess function), range of motion (measured by goniometer), suprapatellar and mid-calf circumferences (to assess swelling). Each of these data sets is collected pre-operatively (on the morning of surgery) and at three time points post-operatively (3, 14 and 30 days).


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria1

  • Patients undergoing elective arthroscopic meniscectomy for meniscal tear(s)

Exclusion Criteria4

  • Previous reconstructive surgery on the same knee
  • Known clotting disorders
  • Known renal impairment
  • Known allergy to tranexamic acid

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Interventions

Administration of tranexamic acid (one dose 1g in 10ml of 0.9% saline solution) or placebo (10ml 0.9% saline solution) intraoperatively. This is administered intravenously by the anaesthetist immediat

Administration of tranexamic acid (one dose 1g in 10ml of 0.9% saline solution) or placebo (10ml 0.9% saline solution) intraoperatively. This is administered intravenously by the anaesthetist immediately post-induction.


Locations(1)

Canterbury, New Zealand

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ACTRN12618001600235