Does the medication 'tranexamic acid' decrease pain and improve function in the short term after arthroscopic meniscectomy?
Prof Gary Hooper
40 participants
Apr 20, 2018
Interventional
Conditions
Summary
The aim of this pilot study is assess the efficacy of tranexamic acid in reducing post-operative pain, swelling and range of motion in patients undergoing arthroscopic meniscectomies. It is a blinded study in which participants are randomised to receive one intraoperative dose of either intravenous tranexamic acid or placebo (saline). Data collected is as follows: pain (0-10 scale), Lysholm knee score and Tegener activity score (to assess function), range of motion (measured by goniometer), suprapatellar and mid-calf circumferences (to assess swelling). Each of these data sets is collected pre-operatively (on the morning of surgery) and at three time points post-operatively (3, 14 and 30 days).
Eligibility
Plain Language Summary
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Interventions
Administration of tranexamic acid (one dose 1g in 10ml of 0.9% saline solution) or placebo (10ml 0.9% saline solution) intraoperatively. This is administered intravenously by the anaesthetist immediately post-induction.
Locations(1)
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ACTRN12618001600235