Combined speech pathology and amitriptyline treatment for vocal cord dysfunction.
Comparison of combined speech pathology and amitriptyline versus speech pathology alone in the treatment of vocal cord dysfunction: a randomised double-blind placebo controlled trial.
LaTrobe University
50 participants
Jan 31, 2020
Interventional
Conditions
Summary
The purpose of this study is to trial a combination treatment of speech pathology and amitriptyline for vocal cord dysfunction and compare this to speech pathology alone. The aim is to reduce the symptoms of vocal cord dysfunction.
Eligibility
Inclusion Criteria1
- Adults with vocal cord dysfunction diagnosed using laryngoscopy. Diagnosis defined as abnormal adduction of the vocal folds during inspiration or > 50% adduction during expiration.
Exclusion Criteria6
- previous speech pathology treatment for vocal cord dysfunction
- contraindications for the use of amitriptyline including pregnancy and breast feeding
- Lung pathology excluding asthma
- progressive neurological condition
- structural vocal fold pathology
- inability to attend study visits
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Interventions
Arm 1 - Amitriptyline 25mg per day for one week, then increased to 50mg per day for one week then increased to maximal dose of 75mg per day for 8 weeks, oral route - oral capsules, combined with speech pathology behavioural intervention. Speech pathology intervention includes education on vocal cord dysfunction and related conditions such as chronic refractory cough, provision of lifestyle strategies, vocal hygiene and behavioural breathing and voice exercises, provided on an individual basis for 6 sessions over 10 weeks, provided by an experienced speech pathologist. Arm 2 - Placebo medication and identical speech pathology behavioural intervention. Adherence to medication and speech pathology intervention will be monitored by unused product return (medication) and participant diary and participant explanation and modelling of exercises (speech pathology intervention).
Locations(1)
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ACTRN12619000158167