RecruitingPhase 4ACTRN12619000221156

Optimising pain relief after knee joint replacement surgery at Counties Manukau Health; We compare two methods of local anaesthesia (numbing medicine) administration to reduce pain after knee replacement surgery.

Comparison of continuous infusion against programmed intermittent bolus of local anaesthesia through adductor canal catheter after total knee arthroplasty.


Sponsor

Counties Manukau Health, Middlemore Hospital Research Office

Enrollment

72 participants

Start Date

May 1, 2019

Study Type

Interventional

Conditions

Summary

We are studying how to optimise pain relief after knee joint operation. An adductor canal catheter (plastic tube placed near the nerve providing sensation to knee) is used to provide numbing medicine called local anaesthesia for pain relief after a knee joint replacement. We are looking at comparing a continuous drip of local anaesthesia versus intermittent delivery of a larger volume of local anaesthesia called a Programmed intermittent bolus (PIB). We will measure the participants satisfaction, overall use of painkillers and how well they can participate in rehabilitation. We will use the findings of this study to help us optimise our pathways for future patients having their knee replacement operation.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 80 Yearss

Plain Language Summary

Simplified for easier understanding

Knee replacement surgery is very effective at relieving chronic knee pain, but managing pain in the days after the operation is critical for recovery. One approach is an adductor canal catheter — a thin plastic tube placed near the nerve that supplies sensation to the knee — which delivers local anaesthetic continuously to numb the area and reduce reliance on strong opioid painkillers. This trial is comparing two different ways of delivering that local anaesthetic: a slow, constant drip versus larger doses delivered at regular intervals (called programmed intermittent boluses, or PIB). Researchers want to find out which method provides better pain control, results in greater patient satisfaction, and allows people to engage more effectively with physiotherapy and rehabilitation after surgery. You may be eligible if you are scheduled to have a primary total knee replacement at Middlemore Hospital or Manukau Surgical Centre and are between 18 and 80 years of age. People with significant kidney or liver problems, allergies to the study medications, or those on high doses of opioid medications prior to surgery would generally not be eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients undergoing Total Knee Arthroplasty will be randomly assigned to one of two groups in a double-blinded manner. They will all receive the established pain relief treatment (Adductor Canal Cathe

Patients undergoing Total Knee Arthroplasty will be randomly assigned to one of two groups in a double-blinded manner. They will all receive the established pain relief treatment (Adductor Canal Catheter - a peripheral nerve catheter) and have 0.2% ropivacaine as the local anaesthetic. 1. Group 1 - Continuous infusion of local anaesthesia at 5mls/hr of 0.2% ropivacaine (10mg/hr) 2. Group 2 - Programmed intermittent bolus of local anaesthesia - 10mls every 2 hours of 0.2% ropivacaine. (20mg every 2 hours) The infusion will start in the postoperative anaesthetic care unit (PACU) and continue for 48 hours after the start of the study drug/method of delivery. We will follow up at least once daily for 72 hours after commencing study infusion, we will check adherence to study protocol and document any violations or deviation from prescribed methods; audit of hospital records, medication charts and participant's responses will be used to monitor adherence to study protocol.


Locations(1)

Counties Manukau Health facilities, Auckland, New Zealand, New Zealand

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ACTRN12619000221156