Brain Oxygenation changes during Heart Surgery
Changes in cerebral mitochondrial oxygenation during paediatric and adult cardiac surgery
Justin Skowno
80 participants
Dec 21, 2020
Observational
Conditions
Summary
The aim of this pilot study is to evaluate the relationship between intraoperative blood pressure and brain metabolism during heart surgery using an advanced non-invasive optical imaging technique . We hypothesise that drops in perfusion pressure (below the limit of cerebral autoregulation) which are frequently encountered in heart surgery, not only impair cerebral haemodynamics, but also affect brain metabolism. This research will extend this extensive programme of research for the first time to the cardiac surgical population. This pilot study will inform the feasibility of future studies comparing [oxCCO] with clinical outcomes following cardiac surgery.
Eligibility
Inclusion Criteria1
- adults and children undergoing heart surgery using cardiopulmonary bypass
Exclusion Criteria1
- cerebral and cranial malformations involving frontal bone and cortex.
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Interventions
Patients undergoing heart surgery will have their brain cytochrome oxygenation status monitoring using the miniCYRIL near infrared system, together with standard clinical monitoring. This data will not be available to clinicians. Monitoring will commence ten minutes prior to surgical incision, and conclude on application of surgical dressings at the end of the operation.
Locations(2)
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ACTRN12619000605190