Topical Dorzolamide for Idiopathic Macular Hole

This study is testing whether eye drops containing dorzolamide — a medication normally used for glaucoma — can help heal a macular hole before surgery is needed. A macular hole is a small gap that forms in the centre of the retina (the light-sensitive layer at the back of the eye), causing distorted or blurred central vision. Currently, the main treatment is a surgical procedure called vitreoretinal surgery, but some people may prefer a less invasive option if one is available. Adults aged 18 and over with an idiopathic (spontaneous, not caused by injury or other conditions) macular hole will be randomly assigned to receive dorzolamide eye drops or no drops before their planned surgery. Researchers will measure whether the hole closes with drops alone, and compare outcomes after surgery for those who did and did not receive drops. You may be eligible if you are 18 or older and have been diagnosed with an idiopathic macular hole in one eye. People with significant kidney impairment (creatinine clearance below 30 mL/min) or other retinal diseases in the affected eye cannot participate. This study is led by the South Australian Institute of Ophthalmology and aims to find out whether a non-surgical approach to macular hole treatment is viable.