RecruitingACTRN12619000661178

Does brain connectivity in healthy adults influence the induction of spatial neglect by non-invasive brain stimulation?

Does parietal cortex connectivity in healthy adults influence the induction of spatial neglect by non-invasive brain stimulation?


Sponsor

University of South Australia

Enrollment

39 participants

Start Date

Dec 3, 2018

Study Type

Interventional

Conditions

Summary

The aim is determine whether connectivity of the right parietal cortex predicts response to an inhibitory brain stimulation paradigm (TBS), to induce spatial neglect in healthy adults. We hypothesis that the connectivity of the stimulated parietal cortex prior to an inhibitory brain stimulation paradigm, will predict the degree of induced left-sided neglect as measured by behavioural responses.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 30 Yearss

Plain Language Summary

Simplified for easier understanding

This study is investigating how the brain's connections — specifically the right parietal cortex, the region responsible for processing space and attention — influence a person's response to a type of non-invasive brain stimulation called theta burst stimulation (TBS). TBS can temporarily reduce activity in a brain region, and researchers are using it to create a short-lived state mimicking spatial neglect (where people lose awareness of one side of space) to better understand this condition. Healthy right-handed adults aged 18–30 will undergo a brain MRI scan to map their brain connectivity before receiving TBS stimulation to the right parietal cortex. They will then complete attention tasks to measure the degree of any induced neglect. The goal is to understand whether individual differences in brain wiring predict how strongly the stimulation affects attention. You may be eligible if you are 18–30 years old, right-hand dominant, and are not taking any medications that affect the nervous system (such as antidepressants or anticonvulsants). People who cannot safely undergo brain stimulation or MRI, who have not given consent, or who are under the influence of alcohol at the time of testing cannot participate. This study is conducted at the University of South Australia and contributes to understanding the brain basis of neglect after stroke.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Transcranial Magnetic Stimulation (TMS) Prior to the continuous theta burst stimulation (cTBS) intervention, the participant’s resting motor threshold (RMT) will be found by using a TMS stimulator (M

Transcranial Magnetic Stimulation (TMS) Prior to the continuous theta burst stimulation (cTBS) intervention, the participant’s resting motor threshold (RMT) will be found by using a TMS stimulator (Magstim Super Rapid stimulator (Magstim Company, Dyfed, UK)) with RMT settings, placed perpendicular to the scalp over the right motor cortex at C4 on the 10/10 EEG cap. Electrodes will be placed over the participant’s left first dorsal interosseous muscle, so that motor evoked potentials can be monitored to devise the individual’s resting motor threshold. 70% of this threshold will then used as the intensity for the cTBS intervention. The same TMS stimulator will then be used to generate a continuous theta burst stimulation (cTBS). The continuous train (bi-phasic wave form) will be delivered using an air-cooled, figure-of-eight coil, which will be held perpendicular to the scalp, by the trained, primary examiner over the right parietal cortex, located at P4 according to the 10/10 EEG system. The cTBS will last for 40 seconds, 600 pulses will be applied in three bursts at 50Hz, repeated at 5 H. The intervention will be delivered once to each participant, face to face at the University of South Australia Clinical Trials Facility.


Locations(1)

SA, Australia

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ACTRN12619000661178


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