Does brain connectivity in healthy adults influence the induction of spatial neglect by non-invasive brain stimulation?
Does parietal cortex connectivity in healthy adults influence the induction of spatial neglect by non-invasive brain stimulation?
University of South Australia
39 participants
Dec 3, 2018
Interventional
Conditions
Summary
The aim is determine whether connectivity of the right parietal cortex predicts response to an inhibitory brain stimulation paradigm (TBS), to induce spatial neglect in healthy adults. We hypothesis that the connectivity of the stimulated parietal cortex prior to an inhibitory brain stimulation paradigm, will predict the degree of induced left-sided neglect as measured by behavioural responses.
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Interventions
Transcranial Magnetic Stimulation (TMS) Prior to the continuous theta burst stimulation (cTBS) intervention, the participant’s resting motor threshold (RMT) will be found by using a TMS stimulator (Magstim Super Rapid stimulator (Magstim Company, Dyfed, UK)) with RMT settings, placed perpendicular to the scalp over the right motor cortex at C4 on the 10/10 EEG cap. Electrodes will be placed over the participant’s left first dorsal interosseous muscle, so that motor evoked potentials can be monitored to devise the individual’s resting motor threshold. 70% of this threshold will then used as the intensity for the cTBS intervention. The same TMS stimulator will then be used to generate a continuous theta burst stimulation (cTBS). The continuous train (bi-phasic wave form) will be delivered using an air-cooled, figure-of-eight coil, which will be held perpendicular to the scalp, by the trained, primary examiner over the right parietal cortex, located at P4 according to the 10/10 EEG system. The cTBS will last for 40 seconds, 600 pulses will be applied in three bursts at 50Hz, repeated at 5 H. The intervention will be delivered once to each participant, face to face at the University of South Australia Clinical Trials Facility.
Locations(1)
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ACTRN12619000661178