RecruitingPhase 4ACTRN12619001752156

Investigating the influence of methylphenidate on perceptual decisions in healthy, young adults

Clarifying the role of methylphenidate on distractor processing through event-related potentials in healthy controls.


Sponsor

Monash University

Enrollment

35 participants

Start Date

May 14, 2021

Study Type

Interventional

Conditions

Summary

This study aims to clarify the role of neurotransmitters dopamine and noradrenaline in distractor processing. While previously shown to improve attention, it is unclear what neural processes underpin this effect. We intend to use EEG analysis, a task that implements distracting stimuli, and administration of a drug that increases transmission of dopamine and noradrenaline (methylphenidate) to help us understand the neural mechanisms of this effect.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 45 Yearss

Plain Language Summary

Simplified for easier understanding

This study is exploring how a common medication called methylphenidate (widely known as Ritalin, often used for ADHD) affects the way our brains filter out distracting information. Researchers at Monash University want to understand the brain chemistry behind our ability to focus — specifically how two chemical messengers, dopamine and noradrenaline, play a role in ignoring things that aren't relevant to what we're doing. Participants will take a single dose of methylphenidate or a placebo and then complete a computer-based task that involves distracting stimuli. Brain activity will be recorded throughout using EEG (a painless headcap that detects electrical signals). By comparing brain responses between the medication and placebo sessions, researchers hope to pinpoint the neural processes that underlie attention. This study is looking for healthy adults aged 18 to 45. Importantly, all four grandparents must be of Caucasian background (to ensure consistent drug absorption rates), and participants must be right-handed. Women must be taking a combined oral contraceptive pill. People who are pregnant, have a history of psychiatric illness, use psychotropic medications, or currently smoke are not eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Drug Intervention A single dose of 30mg of methylphenidate will be administered in one testing session via an oral capsule. A gelatin filled placebo capsule will be administered in the second session

Drug Intervention A single dose of 30mg of methylphenidate will be administered in one testing session via an oral capsule. A gelatin filled placebo capsule will be administered in the second session in a counterbalanced order, with the two sessions separated by 7 days.


Locations(1)

VIC, Australia

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ACTRN12619001752156