RecruitingACTRN12620000162910

Effect of individualised transcranial magnetic stimulation (TMS) on cognitive functioning in healthy volunteers

Effect of individualised site positioning with transcranial magnetic stimulation (TMS) on cognitive functioning in healthy volunteers


Sponsor

UNSW

Enrollment

40 participants

Start Date

Mar 30, 2021

Study Type

Interventional

Conditions

Summary

In this study we propose to investigate the effects of applying TMS using a novel individualised site targeting methodology with a behavioural outcome for the purpose of enhancing cognitive flexibility.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 40 Yearss

Inclusion Criteria1

  • Healthy, right handed, not taking any concurrent medications which may affect TMS effects (e.g., benzodiazepines), free from any neurological or psychiatric disorder, no recent head injury, no history of seizure or stroke, and no current history of drug or alcohol abuse or dependence.

Exclusion Criteria1

  • History of any psychiatric or neurological illness, seizure, stroke, any serious medical conditions, or current pregnancy

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Interventions

A first experimental session will be conducted to determine the 'optimal' and 'suboptimal' sites for transcranial magnetic stimulation (TMS) using a cognitive task. TMS involves the administration of

A first experimental session will be conducted to determine the 'optimal' and 'suboptimal' sites for transcranial magnetic stimulation (TMS) using a cognitive task. TMS involves the administration of strong, high frequency magnetic pulses to the brain. Participants will be required to complete a cognitive task while receiving TMS to different stimulation sites. The 'optimal' site is that where the largest effect of TMS on performance occurs, and the 'suboptimal' site is that where the smallest effect of TMS occurs. The duration of this session is approximately 1 hr. This session will occur approximately 1 week prior to the first intervention session. Arm 1: TMS administered by a university student to an optimised, individualised stimulation site for approximately 3 min at the Black Dog Institute. TMS will involve the administration of strong, high frequency magnetic pulses to the brain. Arm 2: TMS administered by a university student to a suboptimal, individualised stimulation site for approximately 3 min at the Black Dog Institute. TMS will involve the administration of strong, high frequency magnetic pulses to the brain. Arm 1 and Arm 2 will be conducted at least 2 days apart.


Locations(1)

NSW, Australia

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ACTRN12620000162910


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