RecruitingACTRN12620000162910

Effect of individualised transcranial magnetic stimulation (TMS) on cognitive functioning in healthy volunteers

Effect of individualised site positioning with transcranial magnetic stimulation (TMS) on cognitive functioning in healthy volunteers

Sponsor

UNSW

Enrollment

40 participants

Start Date

Mar 30, 2021

Study Type

Interventional

Conditions

Cognitive functioning

Summary

In this study we propose to investigate the effects of applying TMS using a novel individualised site targeting methodology with a behavioural outcome for the purpose of enhancing cognitive flexibility.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 40 Yearss

Plain Language Summary

Simplified for easier understanding

Transcranial Magnetic Stimulation (TMS) is a non-invasive procedure that uses magnetic pulses to gently stimulate specific areas of the brain. Researchers are investigating whether TMS applied to an individually targeted brain site can improve cognitive flexibility — that is, the ability to switch between tasks or adapt thinking in response to new situations. This is a study in healthy volunteers, not patients, making it a low-risk way to understand how TMS might work for future uses. Participants will undergo TMS using a new method that targets each person's brain based on their own neuroimaging data, rather than using a standard location. The study will measure whether this personalised approach leads to better cognitive performance compared to a control condition. You may be eligible if you are a healthy adult aged 18–40, are right-handed, are not currently taking medications that could affect TMS (like benzodiazepines), and have no history of neurological or psychiatric conditions, seizures, stroke, recent head injury, or drug and alcohol dependence.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Print for Your Doctor Check Your Eligibility

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

A first experimental session will be conducted to determine the 'optimal' and 'suboptimal' sites for transcranial magnetic stimulation (TMS) using a cognitive task. TMS involves the administration of

A first experimental session will be conducted to determine the 'optimal' and 'suboptimal' sites for transcranial magnetic stimulation (TMS) using a cognitive task. TMS involves the administration of strong, high frequency magnetic pulses to the brain. Participants will be required to complete a cognitive task while receiving TMS to different stimulation sites. The 'optimal' site is that where the largest effect of TMS on performance occurs, and the 'suboptimal' site is that where the smallest effect of TMS occurs. The duration of this session is approximately 1 hr. This session will occur approximately 1 week prior to the first intervention session. Arm 1: TMS administered by a university student to an optimised, individualised stimulation site for approximately 3 min at the Black Dog Institute. TMS will involve the administration of strong, high frequency magnetic pulses to the brain. Arm 2: TMS administered by a university student to a suboptimal, individualised stimulation site for approximately 3 min at the Black Dog Institute. TMS will involve the administration of strong, high frequency magnetic pulses to the brain. Arm 1 and Arm 2 will be conducted at least 2 days apart.

Locations(1)

NSW, Australia

View Full Details on ANZCTR

For the most up-to-date information, visit the official listing.

Visit

ACTRN12620000162910

Related Trials

Volunteering and Health Study: Does volunteering in the community benefit older adults' cognitive functioning?

ACTRN126170002643811 location