RecruitingACTRN12620000195954

Deferred Cord Clamping to Reduce Need for Neonatal Blood Transfusion: the Transfusions In The APTS Newborns Study (TITANS)

Understanding the Role of Deferred Cord Clamping in Reducing Need for Neonatal Red Cell Transfusion: what can be learned from the Australian Placental Transfusion Study? A retrospective, nested, observational study of APTS newborns

Sponsor

University of Sydney

Enrollment

1,401 participants

Start Date

May 15, 2020

Study Type

Observational

Conditions

Pre-term birth

Summary

The Australian Placental Transfusion Study (APTS) and other studies provide strong evidence that deferring umbilical cord clamping at birth for up to a minute is a simple, safe procedure that reduces the proportion of preterm infants who need a blood transfusion by 10%. The mechanism is not fully understood – but one potential mechanism is an increased volume of transfusion of blood from the placenta to the baby after birth. Alternatively, deferred cord clamping may reduce severity of illness in the first weeks after birth. This could lead to fewer blood tests, greater tolerance of anaemia, and better opportunities for babies to make their own red cells. The Transfusions In The APTS Newborns Study (TITANS) is designed is to obtain and analyse more data about the babies in APTS to investigate the mechanism behind the reduced need for red cell transfusions, and to explore whether there are other changes in clinical care that could reduce the need for transfusion.

Eligibility

Sex: Both males and femalesMax Age: 30 Weekss

Inclusion Criteria1

Enrolled and randomly assigned newborns (>30 weeks gestation) in Australian and New Zealand sites for the Australian Placental Transfusion Study (APTS)

Exclusion Criteria1

APTS participants who withdrew participation from the study

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Interventions

Data from the APTS study combined with other routinely collected clinical data from APTS Australian and New Zealand sites relating to receipt of transfusion and the factors that affect risk for transfusion in preterm infants during their hospital admission after birth will be used for this study. No additional participant contact is required for the study. Data will be collected from patient medical records.