Akynzeo for post-operative nausea and vomiting after bariatric surgery.

Nausea and vomiting after surgery is one of the most common and unpleasant complications of bariatric (weight loss) operations, occurring particularly frequently after laparoscopic (keyhole) procedures. Feeling very sick after surgery can slow recovery, make it harder to stay hydrated, and reduce overall satisfaction. This trial tests whether a combination medication called Akynzeo (which contains two anti-nausea drugs: netupitant and palonosetron) can better prevent post-operative nausea and vomiting in people having bariatric surgery compared to standard anti-nausea treatments. Participants are randomly assigned to receive either Akynzeo or the standard anti-nausea regimen before their operation. Nausea, vomiting, and the need for rescue anti-nausea medications are tracked in the hours and days following surgery. You may be eligible if you are between 18 and 70 years old and scheduled for elective laparoscopic bariatric surgery. A known allergy to any of the study anti-nausea medications, significant psychiatric illness, kidney impairment, or use of medications that interact with the study drugs would make you ineligible.