Assessing whether a highly absorbable curcumin formulation can decrease inflammation and free radical damage in middle aged participants

Curcumin is a well-evidenced and widely administered supplemental compound. Previous studies have demonstrated its capacity to reduce inflammation and associated physical manifestations. A large body of evidence has also confirmed that ingestion can attenuate oxidative damage. However, the bioavailability of naturally occurring curcumin is poor. Fortunately a novel curcumin formulation, using LipiSperse® technology, has been developed which increases plasma curcuminoids concentration three times compared to raw curcumin. While the safety of this novel formulation has been demonstrated (TGA listed) its effectiveness to reduce markers of inflammation and oxidative damage is not yet known. Therefore the objective of this double blind, placebo controlled trial is to investigate, in healthy humans, the efficacy of the novel curcumin formulation (with LipiSperse® technology) to reduce markers of inflammation and oxidative stress compared to both natural curcumin (without LipiSperse® technology) and a placebo control.