Addressing diabetic foot ulcer trajectories through social genomics research

Participants who have been diagnosed with diabetes mellitus will be observed for three years in a longitudinal prospective study. We will be collecting data on two cohorts: Cohort 1: people with a diabetic foot ulcer, and Cohort 2: people with diabetes (and no foot ulcer). Both Cohorts will have a standard set of data collected. This data collection will be through questionnaires and validated tools and will include information on: addiction, medication adherence, sleep disturbance, social adversity, beliefs, diet, activity. We will also collect demographic data (age, sex), medical history (type of diabetes, duration of diabetes, medical diagnoses), cognitive impairment, neurovascular foot assessment and patient reported outcomes (quality of life, wound concerns). Cohort 1: Will have ongoing data collection over the three years. This will be at set timepoints (every 3 months) or if a sentinel event of interest occurs, such as infection, admission to hospital or amputation. We will also collect ongoing information on the ulcer, deterioration and healing and treatment modalities (antibiotics, antimicrobial use, advanced wound care). There will also be a smaller sub analysis group in this cohort, who will have the same data collected, and in addition tissue and blood samples at the set time points. The initial data collection will take approximately 1 hour. Subsequent data collection will take approximately 30 minutes. Cohort 2: Will have a one off data collection. This will take approximately 1 hour to complete.