Diabetes Mellitus Clinical Trials

846 recruitingLast updated: June 17, 2026

There are 846 actively recruiting diabetes mellitus clinical trials across 79 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4, Phase 3, Early Phase 1. Top locations include Boston, Massachusetts, United States, Chicago, Illinois, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Diabetes Mellitus Trials at a Glance

846 actively recruiting trials for diabetes mellitus are listed on ClinicalTrialsFinder across 6 cities in 79 countries. The largest study group is Not Applicable with 364 trials, with the heaviest enrollment activity in Boston, Chicago, and Houston. Lead sponsors running diabetes mellitus studies include Novo Nordisk A/S, Eli Lilly and Company, and Stanford University.

Browse diabetes mellitus trials by phase

Treatments under study

About Diabetes Mellitus Clinical Trials

Looking for clinical trials for Diabetes Mellitus? There are currently 206 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Diabetes Mellitus trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Diabetes Mellitus clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 846 trials

Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled7 locationsNCT06906640
Recruiting
Not Applicable

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Metabolic SyndromeDiabetes Mellitus, Type 2Prediabetes
Cleerly, Inc.7,500 enrolled124 locationsNCT06112418
Recruiting
Not Applicable

Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes

Type 1 DiabetesHypoglycemiaHyperglycaemia Due to Type 1 Diabetes Mellitus+1 more
University of Colorado, Denver150 enrolled1 locationNCT06297980
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled7 locationsNCT06906627
Recruiting
Phase 2

INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes

Type 1 Diabetes Mellitus
Mannkind Corporation100 enrolled10 locationsNCT07224321
Recruiting
Not Applicable

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Type 1 Diabetes MellitusType 2 Diabetes Mellitus
Hoffmann-La Roche270 enrolled18 locationsNCT06704672
Recruiting
Not Applicable

DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions

Obesity, OverweightAsthma (Diagnosis)Type 1 Diabetes+3 more
Adhera Health, Inc.280 enrolled1 locationNCT07638345
Recruiting

An Observational Study Called FINE-REAL Korea to Learn More About the Use of the Drug Finerenone in People With Chronic Kidney Disease and Type 2 Diabetes in a Routine Medical Care Setting in South Korea

Chronic Kidney DiseaseType 2 Diabetes Mellitus
Bayer500 enrolled1 locationNCT07232537
Recruiting

Validity and Reliability of Mixed Reality-Based Functional Mobility Tests in Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
Selcuk University75 enrolled1 locationNCT07649967
Recruiting
Not Applicable

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

Diabetes MellitusDiabetes Mellitus, Type 2Diabetes+8 more
University of Colorado, Denver240 enrolled2 locationsNCT07011147
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Not Applicable

Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

DepressionDiabetes Mellitus, Type 2Depressive Symptoms
University of Michigan80 enrolled1 locationNCT06574035
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Not Applicable

Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy

ObesityObesity Type 2 Diabetes Mellitus
University of South Carolina50 enrolled1 locationNCT07518407
Recruiting
Not Applicable

Impact of Pilates Exercises on Diabetic Erectile Dysfunction.

Pilates ExerciseDiabete MellitusErectile Dysfunction Associated With Type 2 Diabetes Mellitus+1 more
Benha University60 enrolled2 locationsNCT07293156
Recruiting
Phase 3

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Cardiovascular DiseasesHypertensionDiabetes Mellitus, Type 2
Boehringer Ingelheim11,800 enrolled1155 locationsNCT07064473
Recruiting
Not Applicable

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

Obesity, OverweightDehydrationType 2 Diabetes+2 more
State University of New York at Buffalo30 enrolled1 locationNCT07641361
Recruiting

Swiss Diabetes Registry - SwissDiab Study

Diabetes Mellitus
Insel Gruppe AG, University Hospital Bern1,500 enrolled4 locationsNCT01179815
Recruiting
Not Applicable

Pediatric Insulin Plan Calculator for T1DM Management

Type 1 Diabetes Mellitus (T1DM)Type 1 Diabetes MellitusT1DM+1 more
Sultan Qaboos University440 enrolled2 locationsNCT07427134