POMMS: Pre-Operative Misoprostol in Myomectomy Surgery – A Pilot Study

Uterine fibroids are non-cancerous growths in the uterus that can cause heavy bleeding, pain, and pressure symptoms. When fibroids need to be surgically removed — a procedure called myomectomy — one of the main risks is blood loss during the operation. This study is testing whether misoprostol, a medication given under the tongue just before surgery, can reduce bleeding during myomectomy. Misoprostol causes the uterus to contract, which may help limit blood flow to the fibroid and reduce intraoperative blood loss. Participants are randomly assigned to receive either misoprostol or a placebo before their surgery, and neither the patient nor the surgeon knows which was given until after the study. You may be eligible if you are a woman aged 18 or older who is scheduled for either an open (abdominal) or laparoscopic (keyhole) myomectomy and agree to take part. Women with an allergy to misoprostol or prostaglandins, or who are pregnant or breastfeeding, are not eligible.