Oropharyngeal gonorrhoea detection using mouthwash overtime (OMEGA3)

The intervention is Listerine® Zero mouthwash. At the commencement of the study (i.e. before receiving the mouthwash intervention, t=0), the research nurse will take two throat swabs (covering the tonsillar fossae and posterior pharyngeal wall) at baseline before they receive the mouthwash intervention. Participants will be asked to provide a saliva sample with the instruction provided by the research nurse. After collecting the throat swabs and saliva samples at baseline (t=0), participants will be instructed to use the allocated mouthwash by rinsing and gargling 10mls of the mouthwash into the back of their throat for 30 seconds (rinse for 15 seconds then gargle for 15 seconds) and then to discard the mouthwash. They will then be instructed to use the spray bottle provided to spray the mouthwash 15 times to the back of their throat and spitting the excess. The same composition of mouthwash will be used for rinsing/gargling as well as spraying with no alteration. Participants will be asked to use the mouthwash once at t=0, no mouthwash will be used after this time point. Participants will be supervised by a research nurse when using the mouthwash. The mouthwash intervention will be administered by the research nurse. After the mouthwash regime has been completed, the research nurse will set a timer for five minutes (t=5). At five minutes the research nurse will then take two throat swabs and a saliva sample. This process will be followed the same at time points of 30 minutes (t=30), 60 minutes (t=60), and 120 minutes (t=120). Composition of Listerine® Zero mouthwash: Water, Sorbitol, Propylene Glycol, Sodium Lauryl Sulfate, Poloxamer 407, Eucalyptol, Benzoic Acid, Sodium Benzoate, Methyl Salicylate, Thymol, Sodium Saccharin, Menthol, Sodium Fluoride, Flavour, Sucralose, CI 42053.