Role of celecoxib in postoperative analgesia in paediatric tonsillectomy: a double-blinded, placebo-controlled randomised controlled trial
Gosford Hospital
140 participants
Feb 25, 2022
Interventional
Conditions
Summary
Pain after tonsillectomy is widely recognised to be not fully controlled by current pain management methods, especially in children. The aim of the study is to find out whether the use of the medication celecoxib will be useful in reducing this pain. The hypothesis is that celecoxib will be safe and effective to manage pain in children after tonsillectomy.
Eligibility
Inclusion Criteria2
- Patients aged 3-16 years
- Patients undergoing tonsillectomy with or without adenoidectomy
Exclusion Criteria7
- Patients:
- Allergy to non-steroidal anti-inflammatory drugs (NSAIDs), opioids, paracetamol, or sulphonamides
- Significant comorbidities unfit for treatment with selected intervention
- Already taking NSAIDs, opioids or paracetamol on a regular basis
- Patients taking drugs that interact with opioids, paracetamol or NSAIDs
- History of peptic ulcers or gastrointestinal bleeding
- Females who are pregnant or nursing
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Interventions
Celecoxib at dose of 2mg per kg of body weight, taken twice daily, orally in liquid form for 14 days AND Paracetamol at dose of 15mg per kg of body weight, four times a day, orally in liquid form for 14 days AND Oxycodone liquid orally, at 0.1mg per kg of body weight, as required (up to four times a day) These medications will be started on the day of tonsillectomy. Adherence will be monitored by self-report by the patients and/or their guardians on the questionnaires.
Locations(2)
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ACTRN12621001390875