RecruitingACTRN12621001711808

Gastric emptying and hormonal changes in idiopathic reactive hypoglycaemia following a mashed potato meal

Gastric emptying and incretin hormones in idiopathic reactive hypoglycaemia following a mashed potato meal

Sponsor

The University of Adelaide

Enrollment

40 participants

Start Date

Dec 13, 2021

Study Type

Interventional

Conditions

idiopathic reactive hypoglycaemia

Summary

In some people, blood glucose levels become low (‘hypoglycaemic’) after a meal and cause symptoms such as shakiness, sweatiness and difficulty concentrating. These symptoms can be bothersome and may be severe. Current approaches to manage this condition, so-called ‘idiopathic reactive hypoglycaemia’, are limited as we do not know what is causing the blood glucose level to drop. When food passes through the intestine, various ‘hormones’ that influence blood glucose levels enter bloodstream. While this is a useful to prevent an abnormal elevation in blood glucose after a meal, we think individuals who have low blood glucose levels after eating may have abnormally fast movement of food through the stomach and intestine leading to increased release of these ‘hormones’. This study is designed to investigate this possibility and if shown to be the case, this would provide a basis for logical, and hopefully, more effective treatment for ‘idiopathic reactive hypoglycaemia’.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

Some people experience episodes of shakiness, sweating, and difficulty concentrating after eating — not because they have diabetes, but because their blood sugar drops too low after a meal. This is called idiopathic reactive hypoglycaemia, and doctors don't fully understand why it happens. One theory is that food moves through the stomach and intestines too quickly in these individuals, triggering an unusual hormonal response that causes blood sugar to crash. This study is investigating that theory. Participants will eat a standardised mashed potato meal while researchers measure how quickly food leaves the stomach and which hormones are released into the bloodstream. By comparing people with reactive hypoglycaemia to healthy volunteers, the team hopes to understand what's going wrong — and why. If the fast-stomach theory is confirmed, it could lead to more logical and effective treatments for this frustrating condition. You may be eligible if you are aged 18 to 70, have been diagnosed with idiopathic reactive hypoglycaemia by a doctor, and do not have diabetes or take medications that affect digestion or blood sugar.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Participants will be given a mashed potato meal consisting of 65g dry potato powder, 20g glucose, 20g margarine labelled with 20 MBq 99mTc-sulfur colloid and 250 ml water (1808 kJ). This meal will be

Participants will be given a mashed potato meal consisting of 65g dry potato powder, 20g glucose, 20g margarine labelled with 20 MBq 99mTc-sulfur colloid and 250 ml water (1808 kJ). This meal will be consumed over 5 minutes. Following this, gastric emptying data will be acquired in 1-min frames for the first 60 minutes, followed by 3-minute frames for 240 minutes following complete consumption of the meal. The meal will be administered by a trained medical officer and will be consumed over 5 minutes, supervised by the medical officer, at the research facility. A gastric ‘region-of-interest’ will be drawn to derive emptying curves and the amount of the meal remaining in the stomach will be calculated. Caecal arrival time will be calculated as the time taken for the labelled drink to travel from the mouth to the caecum using a cobalt marker placed over the right iliac fossa. The time taken for 50% of the meal to be emptied from the stomach will be measured using scintigraphy. All components are expected to be completed within a single 6 hour session. This intervention will be applied once only per participant.

Locations(1)

SA, Australia

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ACTRN12621001711808