RecruitingACTRN12622000039785

Management of secondary postpartum haemorrhage

Structured guidance in the management of secondary post-partum haemorrhage: A prospective cohort study involving women presenting to a single tertiary Womens' hospital.


Sponsor

Mercy Hospital for Women

Enrollment

120 participants

Start Date

Jul 1, 2021

Study Type

Observational

Conditions

Summary

The spectrum of illness in secondary PPH is vast. While some patients experience severe bleeding with haemodynamic instability, or even maternal death, more commonly the vaginal bleeding is less than with a primary PPH. However, the morbidity is still considerable, with many women requiring blood transfusion and surgical interventions such as hysterectomy (Hoveyda & MacKenzie, 2003). Breastfeeding, newborn bonding, and peripartum mental health are also impacted when prolonged inpatient care or repeated outpatient reviews are required. There are no randomised controlled trials or other high-quality research data to guide best management for women who present with a secondary PPH (Mavrides et al, 2016). With the exception of certain antibiotic regimes for postnatal endometritis, current management options for secondary PPH are, at best, based on Level 3 and Level 4 evidence. As such, most institutions and professional bodies do not have a specific policy or guideline to assist clinicians managing this relatively common complication, nor are there audit systems in place to assess safety and success of management. This prospective project aims to recruit women attending a single institution for the management of secondary PPH. This women will have baseline antenatal, intrapartum and postnatal data entered and then be invited to participate in a longitudinal study collecting survey-based data every 6months for 36months. A nested cohort study will arise from the patients managed surgically (group managed with traditional suction curette, compared to those managed hysteroscopically).


Eligibility

Sex: FemalesMin Age: 18 YearssMax Age: 50 Yearss

Inclusion Criteria4

  • Delivery occurred at gestation >20.0 weeks
  • Presentation to ED with secondary PPH more than 24 hours and less than 12 weeks post-partum
  • Competent to provide consent
  • Sufficient English language proficiency to provide written consent and complete follow-up questionnaires

Exclusion Criteria2

  • Clinically unfit (eg unstable) to provide consent
  • Insufficient English to consent or complete questionnaires

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Interventions

Patients presenting 24hours - 12 weeks following birth (>20 weeks gestation) with abnormal vaginal bleeding or retained products of conception on ultrasound will be invited to participate in a longitu

Patients presenting 24hours - 12 weeks following birth (>20 weeks gestation) with abnormal vaginal bleeding or retained products of conception on ultrasound will be invited to participate in a longitudinal observational study. The clinician will enter data collected from existing medical records (without active input from participants), as well as prospectively collected data at time of the initial presentation (again without active input from the participant. Participants will then be required to complete a 10 minute online questionnaire on their health and fertility outcomes every 6 months for 36 months. Exposures of interest: 1. Surgical management of postpartum haemorrhage (PPH) 2. Hysteroscopic treatment of retained products of conception


Locations(1)

Mercy Hospital for Women - Heidelberg

VIC, Australia

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ACTRN12622000039785


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