Assessing the impact of the size of a maxillary sinus graft and its contact with surrounding sinus walls on bone regeneration
Graft contact area to volume ratio – a critical factor in new bone formation after maxillary sinus augmentation in adults?
University of Queensland
50 participants
Mar 13, 2023
Observational
Conditions
Summary
Based on the graft healing after maxillary sinus augmentation, the fraction of new bone formation is hypothesized to be positively correlated to the area of resident bone walls in contact with the bone graft and negatively correlated to the volume of the graft. The inter-relation of these parameters on new bone formation has never been investigated. As such, the ratio of surface area in contact with the graft and the graft volume will be explored in this study.
Eligibility
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Interventions
70 patients included in this trial will be undergoing maxillary sinus augmentation for the purposes of dental implant rehabilitation. This procedure allows new bone formation thereby facilitating dental implant placement. The extent of new bone formation will be measured histologically and correlated to sinus graft volume and degree of contact this graft has with surrounding bone walls. The surgical procedures will be carried out by specialist clinicians (periodontists) with at more than 15 years experience in a specialist private practice. A bone sample will be collected at the time of dental implant placement (6 months after grafting surgery). Histological preparation and measurements will be performed at a university laboratory using well established protocols and an experienced scientific team. This procedure is routinely performed in patients requiring dental implant rehabilitation in the posterior maxilla in situations of insufficient bone due to maxillary sinus pneumatization. The same procedure will still be carried out when clinically indicated in patients who elect to not participate in this trial or withdraw at any time.
Locations(1)
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ACTRN12622000054718