RecruitingACTRN12622000552785

Multiple Arterial Revascularization versus Single in a patients with coronary artery disease

Evaluation of using multiple or single arterial coronary bypass grafts on major adverse cardiac events in patients with coronary artery disease


Sponsor

Ministry of Science and Higher Education

Enrollment

300 participants

Start Date

Sep 24, 2020

Study Type

Interventional

Conditions

Summary

Multiple arterial grafts during CABG increase postoperative survival as compared to a single arterial graft, especially in the long-term period. The study purpose is demonstrate that use of 2 or more arterial grafts for elective primary surgical revascularization in patients with multivessel disease is associated with a reduction in mortality, stroke, heart attack, and repeat revascularization.


Eligibility

Sex: Both males and femalesMin Age: 40 YearssMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

Coronary artery disease occurs when the arteries supplying the heart become narrowed or blocked by fatty deposits. When medication is not enough, bypass surgery (CABG) can reroute blood flow around the blockages using blood vessels from elsewhere in the body. One of the most important choices during bypass surgery is how many arterial grafts to use — veins taken from the leg are commonly used but may not last as long as arteries. This study investigates whether using two or more arterial grafts, rather than just one, leads to better long-term outcomes. Previous research suggests multiple arterial grafts may reduce the risk of death, stroke, heart attack, and the need for repeat procedures over the following years. This trial seeks to confirm that benefit in a prospective study. You may be eligible if you are between 40 and 70 years old and have multivessel coronary artery disease requiring elective primary bypass surgery. People who need additional procedures such as valve surgery or aortic surgery performed at the same time are not eligible for this particular study.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

A randomized study comparing two groups of patients undergoing coronary artery bypass grafting (CABG) at our institute. Patient first group underwent multiarterial coronary bypass surgery (left and ri

A randomized study comparing two groups of patients undergoing coronary artery bypass grafting (CABG) at our institute. Patient first group underwent multiarterial coronary bypass surgery (left and right mammary arteries, radial artery). Materials: Two hundred patients listed for CABG Procedures: All CABGs were performed through a median sternotomy during cardiopulmonary bypass. Full heparinization was given. It anticipated to take an additional 20 minutes for multiarterial coronary bypass surgery Who: heart surgeon with 10 years experience Mode of delivery: face to face Number of times: twice / week to the surgeon performing the CABG procedure All participants will be followed for up to 12 years after the initial surgery.


Locations(1)

Tomsk, Russian Federation

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