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CompletedPhase 1ACTRN12622000823774

Individualization of caffeine supplementation in sports based on the analysis of heart rate variability (HRV)

Individualization of caffeine supplementation in adult athletes aged 18 to 30 based on the analysis of HRV

Sponsor

Poznan University of Medical Sciences

Enrollment

300 participants

Start Date

Jul 12, 2022

Study Type

Interventional

Conditions

Exercise performance

Summary

The aim of the study is to define the principles of caffeine supplementation in sports based on heart rate variability (HRV) analysis. The study aims to capture the individually variable characteristics that influence the level of objective response of the body to different doses of caffeine. Participants will be randomly divided into 3 groups (placebo, 3 mg/kg, and 6 mg/kg body weight). We hypothesize that explaining the relationship between muscle response and HRV to caffeine doses will allow detailed recommendations to athletes.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 30 Yearss

Inclusion Criteria1

  • Healthy athletes and healthy volunteers

Exclusion Criteria14

  • lack of informed consent to participate in research,
  • hypersensitivity to caffeine due to the polymorphism of the CYP1A2 gene
  • diseases of the cardiovascular system,
  • chronic disease impairing the functioning of the musculoskeletal system,
  • diabetes,
  • epilepsy,
  • pregnancy,
  • infections,
  • inflammatory diseases,
  • stroke history,
  • oncological diseases,
  • electronic life support systems (pacemakers, active prostheses, etc.)
  • use of preparations that interact with caffeine, i.e. ephedrine, theophylline, and echinacea
  • hypertension (over 140/90 mmHg)

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Interventions

In the study, caffeine consumption is investigated at a dosage of 3 (group A) and 6 mg/kg body weight (group B). Caffeine will be administered orally in a single dose, based on body weight, in clear

In the study, caffeine consumption is investigated at a dosage of 3 (group A) and 6 mg/kg body weight (group B). Caffeine will be administered orally in a single dose, based on body weight, in clear cellulose capsules (hydroxypropylmethylcellulose 100%). Participants will be instructed to avoid foods containing caffeine for 24 hours prior to testing. All measurements will be taken between 8:00 am and 3:00 pm. The caffeine dose will be randomly selected. All measurements will be performed in university laboratories. After ingestion of caffeine, participants will be continuously supervised until the end of the measurement and for the following 24 hours.

Locations(1)

Poland

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