RecruitingACTRN12623000293662

Assessing diet, exercise, sleep and other lifestyle habits in people with a known increased risk for bowel cancer and who have regular colonoscopies

Dietary and lifestyle behaviour and their association with risk for bowel cancer and pre-Cancerous lesions in individuals undergoing regular colonoscopies

Sponsor

Flinders University

Enrollment

5,000 participants

Start Date

Oct 2, 2023

Study Type

Observational

Conditions

Colorectal Neoplasia

Summary

This study will explore how diet and lifestyle, as well as age and gender (and other non-modifiable risk factors), are involved in the development of bowel cancer and pre-cancerous lesions (adenomas) in people considered at above average risk for bowel cancer due to either family history of bowel cancer or prior history of colorectal adenoma. Who is it for? Individuals are eligible to join this study if they are aged 18 years or older, and are currently enrolled in the Southern Cooperative Program for the prevention of colorectal cancer (SCOOP) Program for a surveillance colonoscopy. Study details: All individuals enrolled in the SCOOP program will be invited to complete and return an online or paper survey at years 1, 2 and 3, which will ask questions on diet, exercise, sleep and other lifestyle factors. The results from each survey and the changes in lifestyle over the 3 years will be compared to the findings at the regular surveillance colonoscopies, in particular the presence of advanced colorectal neoplasia (adenoma or cancer). It is hoped that the results of the study will improve the understanding of the interactions between diet and lifestyle behaviour, with the non-modifiable risk factors on the development of advanced neoplasia. It is hoped that this will be useful for identifying high-risk individuals who may benefit from targeted interventions to reduce their risk of developing bowel cancer and reducing the need for unnecessary colonoscopies for lower risk patients.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

Bowel cancer (colorectal cancer) is one of the most common cancers in Australia, but it can often be prevented if pre-cancerous growths called adenomas are found and removed early. People at higher risk — such as those with a family history of bowel cancer or who have previously had adenomas — undergo regular surveillance colonoscopies through programs like the SCOOP Program. This study is exploring how diet and lifestyle habits influence the development of adenomas and cancer in this higher-risk group. All participants enrolled in the SCOOP surveillance program will be invited to complete an online or paper questionnaire about their diet, physical activity, sleep, and other lifestyle factors at years 1, 2, and 3. The questionnaire results will be compared against the findings from their regular colonoscopies — particularly whether advanced pre-cancerous lesions are found — to identify which lifestyle factors increase or decrease risk. You may be eligible if you are 18 or older and are currently enrolled in the SCOOP Program for surveillance colonoscopy, either because you have a family history of bowel cancer or because you have previously had adenomas or colorectal cancer. The only reason for exclusion is if you are unable to complete the survey due to language or cognitive difficulties.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

We propose to conduct a prospective observational study to investigate how change in diet and lifestyle patterns over time impacts the development of precancerous colorectal lesions or colorectal cancer in individuals at above average risk of colorectal cancer and undergoing a colonoscopy surveillance - the 'Southern Cooperative Program for the prevention of colorectal cancer' (SCOOP). Data regarding patients' colonoscopies will be extracted from the SCOOP database. Participants enrolled in the SCOOP program will be invited to complete the diet and lifestyle survey over the period of three years (in years 1 (baseline survey), 2 and 3 (follow-up surveys)). The survey can be completed by the participants either online, by clicking on a provided link or scanning a QR code. It is expected that each survey will require around 40-50 minutes to be filled out. The exposure variables include: - Dietary intake (using a validated food frequency questionnaire from the Australian Eating Survey), - Physical activity (using the International Physical Activity Questionnaire (IPAQ-L)), - Sleep patterns (Pittsburgh Sleep Quality Index (PSQI), Obstructive sleep apnoea screening questionnaire (OSAS), and Insomnia Severity Index questionnaire, - Smoking status, - Body mass index (BMI), - Aspirin intake, and - Comorbidities including diabetes.