Maternal OXygen Immediately before birth: The MOXIE feasibility study
Douglas Blank
45 participants
Oct 9, 2024
Interventional
Conditions
Summary
We aim to determine if maternal oxygen supplementation 5-10 min prior to birth of term and near-term infants (32 weeks gestation or above at birth) utilising heated humidified high flow nasal cannula with 100% oxygen at 30-70L/min is feasible at both caesarean section and vaginal births. The information gained from this feasibility study will inform the planned randomised controlled trial of maternal oxygen in very preterm infants.
Eligibility
Inclusion Criteria1
- Expecting women between 32 weeks and 0 days to 41 weeks and 6 days gestational age giving birth
Exclusion Criteria5
- History of severe maternal epistaxis
- History of major nasal/sinus surgery or pathology
- Concurrent maternal chronic obstructive pulmonary disease (COPD) exacerbation
- Fetus with congenital abnormality that would alter the expected SpO2 targets in the minutes after birth; ie antenatal diagnosis of ductal dependant cardiac lesions, congenital diaphragmatic hernia, etc.
- Monochorionic twins with evidence of twin-to-twin transfusion syndrome or multiples of more than 2.
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Interventions
Maternal oxygen supplementation via heated humidified high flow nasal cannula for 5-10 minutes at 100% oxygen at 30-70L/min before umbilical cord is clamped. Adherence will be monitored in person by one of two principal investigators and will be documented in study database
Locations(1)
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ACTRN12623001037695