SOCRATES PILOT: Standard of Care Randomised Treatment Evaluation Studies

The SOCRATES pilot study aims to assess the feasibility of randomising different Standard of Care (SoC) treatment options for a range of medical conditions. "Standard of care" refers to the treatment that a patient would usually be given for their health condition and is recommended by experts and scientific studies. There may be more than one SoC treatment for a medical condition. The medical conditions and SoC options included in this study are: 1) Recurrent glioblastoma SoC 1. Lomustine alone SoC 2. Bevacizumab alone 2) Non-metastatic castration-resistant prostate cancer SoC 1. Darolutamide SoC 2. Apalutamide SoC 3. Enzalutamide 3) Metastatic castration-resistant prostate cancer SoC 1. Abiraterone and prednis(ol)one SoC 2. Enzalutamide 4) Metastatic castration-sensitive prostate cancer SoC 1. Apalutamide SoC 2. Enzalutamide 5) Maintenance PARPinhibitor for primary ovarian cancer with BRCA mutation SoC 1. Olaparib SoC 2. Niraparib 6) Adjuvant Treatment for ER+ early breast cancer in post-menopausal women SoC 1. Letrozole SoC 2. Anastrozole 7) HER2-negative advanced breast cancer after failure of anthracycline SoC 1. Paclitaxel SoC 2. Nab-Paclitaxel 8) Deep vein thrombosis (DVT) SoC 1. Rivaroxaban SoC 2. Apixaban 9) Post Myocardial Infarction (MI) SoC 1. Cardiac rehab via telehealth SoC 2. Cardiac rehab in person 10) People with office BP>120/80 and <150/90 in the setting of primary prevention of cardiovascular disease (CVD) SoC 1. Changes to lifestyle (nutrition, physical activity and smoking status) SoC 2. BP lowering medications (any ACE inhibitor or Angiotensin II receptor blocker, dose discretionary) 11) Non-valvular atrial fibrillation SoC 1. Rivaroxaban SoC 2. Apixaban 12) Previous Myocardial Infarction (MI)/Stroke SoC 1. Atorvastatin SoC 2. Rosuvastatin 13) Heart Failure with Reduced Ejection Fraction (HFrEF) without Diabetes mellitus (DM) SoC 1. Empagliflozin SoC 2. Dapagliflozin 14) Hospital admission with first episode paroxysmal Atrial Fibrillation (AF) SoC 1. Metoprolol SoC 2. Sotalol Participants will discuss the SoC options for their medical condition with their doctor. If the doctor recommends more than one SoC option for this participant, they would be invited to participate in the Study. Based on their own preference, participants will either have their SoC option determined by randomisation (randomised cohort) or they will choose their SoC option in consultation with their doctor (non-randomised cohort). The randomized cohort is the 'intervention' group for SOCRATES pilot study. The recruitment period is of two years. Each recruited study participant will be followed up for twelve months post registration to the study.