Oral safety and efficacy of eucalypt sap resin in the management of recurrent vulvovaginal candidiasis

Recurrent vulvovaginal candidiasis (RVVC) — commonly known as recurrent thrush — affects many women and can cause persistent discomfort, itching, and disruption to daily life. Existing antifungal treatments are effective short-term but are not ideal for long-term use, and many women also notice gut symptoms they associate with candida overgrowth. This study explores whether eucalypt sap resin, a natural plant-derived ingredient, might offer a safe alternative. Participants will take a low dose of eucalypt sap resin daily for six months, with vaginal swabs and questionnaires used to track whether thrush episodes decrease and gut symptoms improve. The study also carefully monitors safety to ensure the ingredient is well-tolerated when consumed internally over an extended period. You may be eligible if you are a woman aged 18 to 65 with medically diagnosed recurrent thrush and gastrointestinal symptoms, who is using contraception and not pregnant. People taking anticoagulants, immunosuppressants, antifungals, antibiotics, or corticosteroids, or those with serious chronic conditions such as inflammatory bowel disease, autoimmune disorders, or active cancer are not eligible.