The efficacy of ondansetron as an adjunct to lidocaine compared with lidocaine pretreatment in reducing pain on propofol injection: A randomized controlled trial
The efficacy of ondansetron as an adjunct to lidocaine compared with lidocaine pretreatment in reducing pain on propofol injection: A randomized controlled trial.
King Chulalongkorn Memorial Hospital
260 participants
Aug 3, 2023
Interventional
Conditions
Summary
Ondansetron was proved to decrease pain on propofol injection. Lidocaine also has a role on pain on propofol injection. This study is aimed to determine efficacy of ondansetron as an adjunct to lidocaine in pain on propofol injection compared with lidocaine alone.
Eligibility
Inclusion Criteria5
- ASA classification I-II
- scheduled for elective surgery with general anesthesia
- Age 18- 60 years old
- Weight more than 50 kg.
- cooperate and able to communicate
Exclusion Criteria9
- patient's refusal
- did not use propofol as induction agent
- IV catheter 20G can't be accessed
- local infection at IV site
- Allergic to ondansetron or lidocaine
- History of cardiac arrhythmia
- unable to assess the pain score
- chronic pain or receive analgesic 24 hours before surgery
- RSI technique was used
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Interventions
20mg lidocaine (2% preservative-free) with 4mg ondansetron was prepared and was administered intravenously at the 3-way stop cock in 5 seconds by the nurse then the 3-way stop cock was locked for 15 seconds before 50 mg of propofol was administered in 5 seconds by the anesthesiologist.
Locations(1)
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ACTRN12624000248561