Not Yet RecruitingPhase 3ACTRN12624000324516

Influence of Clindamicyn and Amoxicillin in early dental implant failure

Influence of preoperative clindamicyn and amoxicillin in reducing early dental implant failure. A randomised controlled clinical trial.

Sponsor

Diego Pradillo Gallego

Enrollment

82 participants

Start Date

Jun 18, 2024

Study Type

Interventional

Conditions

early dental implant failure

Summary

The purpose of the study is to compare the use of preoperative Clindamycin 600mg in non allergic penicillin patients in comparison with 2g Amoxicillin 1h before dental implant surgery in relation with early dental implant failure. In penicillin allergic patients there is an increase of early dental implant failure when clindamycin is used in comparison with non allergic when amoxicillin is used. There is only one clinical trial comparing Clindamycin versus placebo. All the previous studies use a postoperative antibiotic regimen with clindamycin that may affect increasing early dental implant failure.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria2

Susceptible healthy patients for dental implants in molars and premolars at least 18 years old.
Periodontal controlled patients

Exclusion Criteria14

Inmunocompromised patients
Diabetes patients
Areas in which a bone or soft tissue regeneration is needed
Post extraction dental implants
Inmediate loading dental implants
allergy to any drugs used in the trial
Decompensated systemic pathologies (cardiac, respiratory,
endocrine, metabolic, hepatic, haematological, the risk of
bacterial endocarditis, or immunosuppression)oking patients
Smokers
history or use of bisphosphonates, anticoagulants, or antiplatelet agents
Patients with amannesis reports that they have had been irradiated in the cervical and
maxillofacial territory, were pregnant, suspected of being pregnant or
breastfeeding, or with a history of antibiotic-associated ulcerous colitis.

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Interventions

Prophylactic use of Clindamycin 600mg or Amoxicillin 2g 1hour prior dental implant surgery. In both cases the mode of administration by oral tablets. In order to monitor the patient adherence, they

Prophylactic use of Clindamycin 600mg or Amoxicillin 2g 1hour prior dental implant surgery. In both cases the mode of administration by oral tablets. In order to monitor the patient adherence, they will return the drug tablet after the administration.

Locations(1)

Granada, Spain

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ACTRN12624000324516