Effects of Paracetamol and Ibuprofen on wound healing in dental extraction patients.
Evaluating and Comparing the Effects of Paracetamol and Ibuprofen on Wound Healing, MMP-9, and TGF-beta1 Levels in Patients Following Upper Third Molar Tooth Extraction.
Residency Training Program in Oral and Maxillofacial, Surgery, Faculty of Dentistry, Chiang Mai University
20 participants
Oct 20, 2022
Interventional
Conditions
Summary
Previous study conducted on animals found that ibuprofen, as a conventional NSAIDs, can delay wound healing, leading to malunion and weakening the strength of the newly formed bone due to anti-inflammatory effects. This study compared the wound healing and anti-inflammatory effects of paracetamol and ibuprofen on tooth extraction wounds in patients. The results found that ibuprofen can inhibit the inflammatory process and delay healing the extraction socket shortly. After discontinuing the medication, healing effect was not different between paracetamol and ibuprofen group.
Eligibility
Exclusion Criteria1
- The terms of exclusion were as follows: 1) Patients who were pregnant, heavy smokers, allergic to paracetamol, ibuprofen, or any anesthetic medications (e.g., mepivacaine and epinephrine-related drugs). 2) Patients who had undergone any pre-existing medical conditions such as hypertension, diabetes, liver disease, kidney disease, blood clotting disorders, and gastritis. 3) Patients who had wounds/injuries in various parts of their bodies prior to initiating the experimental study or those that had severe gingival inflammation (Gingival index > 2). 4). Patients who had taken medication or dietary supplements that could impact the wound healing process. 5) Patients who experienced psychological or communication disorders.
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Interventions
The volunteer participants were divided into 2 groups using the Block Randomization method as follows: Group 1: Participants in this group were administered with 500 milligrams of Paracetamol after tooth extraction. They were instructed to take 1 tablet every 6 hours, totaling 10 tablets. Group 2: Participants in this group were administered with 400 milligrams of Ibuprofen after tooth extraction. They were instructed to take 1 tablet after meals, totaling 10 tablets. Both groups of volunteers will receive a checklist to remind them to take their medication as prescribed by the dentist and volunteers must bring the checklist to the dentist on the follow-up day.
Locations(1)
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ACTRN12624000595516