The effect of anesthetic gases on blood values in middle ear surgeries

Our study will include 100 patients scheduled for middle ear surgery (patients who will undergo tympanoplasty or masteidectomy surgery and who have no active infection, body mass index (BMI) <35, aged 18 to 65 years, ASA I-II who agree to participate in the study). Patients will receive standard anesthesia induction (Propofol, rocuronium, fentanyl) and will be endotracheally intubated and connected to the anesthesia device. Patients will be divided into 2 groups. Sevoflurane group will be started with Sevoflurane 1 minimal alveolar concentration (min: 2% - max: 2.5%) as inhalation anesthetic by adjusting the vaporizer. In the desflurane group, The vaporizer will be set and started with desflurane 1 minimal alveolar concentration (min: 6% - max: 9%) as inhalation anesthetic. The first blood sample will be taken from the finger immediately after the inhalation anesthetics are started. Control of inhalation anesthetics used in the groups and vaporizer settings will be done by the anesthesiologist. After the surgical procedure is finished and inhalation anesthesia is stopped, the second blood sample will be taken. Samples will be taken from the fingertips of the patients and absorbed on gutrie paper. Samples will be taken by the anesthesiologist. Total Free amino acid profile will be studied and statistical analysis will be performed. The assignment of patients to groups will be allocated sequentially.