Efficacy of a ubiquinone based combination therapy in reducing pain in people with diabetes-related painful peripheral neuropathy.

Diabetic peripheral neuropathy is a common and often painful complication of type 2 diabetes, where the nerves — especially in the feet and legs — become damaged due to high blood sugar levels over time. The burning, stabbing, or shooting pain it causes can be severe and difficult to treat with standard medications. This study is investigating whether a combination of over-the-counter supplements targeting how cells produce energy (mitochondrial function) can reduce this nerve pain. The supplements being tested are known to support the energy-producing parts of cells (mitochondria), which are thought to play a role in nerve damage in diabetes. Participants will take the supplement combination for a defined period and report their pain levels using a validated questionnaire before and after treatment. You may be eligible if you are an adult aged 18 or older who has been diagnosed with type 2 diabetes as an adult and has diabetes-related painful nerve damage confirmed by a standardised screening tool. People with active foot ulcers, severe kidney disease, liver cirrhosis, blood clotting disorders, or current pregnancy are not eligible.