RecruitingACTRN12624000860561

Intermittent Phototherapy vs Continuous Phototherapy in Treating Neonatal Jaundice - A Randomized Controlled Trial

Changes in Bilirubin with Intermittent Phototherapy vs Continuous Phototherapy for Treating Neonatal Jaundice - A Randomized Controlled Trial


Sponsor

Universiti Sains Malaysia

Enrollment

74 participants

Start Date

Aug 1, 2024

Study Type

Interventional

Conditions

Summary

This is a randomized controlled trial to compare the effectiveness of intermittent phototherapy vs continous phototherapy in treating neonatal jaundice. Our hypothesis is intermittent phototherapy is as effective as continuous phototherapy. If our hypothesis is proven in this study, thus we can apply intermittent phototherapy in our practice. By using the data, we can practice daycare phototherapy to minimize ward congestion and improve resources management.


Eligibility

Sex: Both males and femalesMin Age: 24 HourssMax Age: 14 Dayss

Inclusion Criteria5

  • Bilirubin level must be within 50umol/L from phototherapy level based on age
  • Age must be more than 24 hours but less than 2 weeks of life
  • Gestational age more than 38 weeks
  • Birth weight more than 2.5kg
  • Low risk based on Malaysia Paediatric Protocol in which subjects do not have the following risk factors : ABO incompatibility, Glucose-6-phosphate dehydrogenase (G6PD) deficiency, clinical sepsis, Rhesus isoimmunization, asphyxia

Exclusion Criteria3

  • severe jaundice required intensive phototherapy
  • syndromic babies
  • had risk factos such as ABO incompatibility, G6PD deficiency, clinical sepsis, Rhesus isoimmunization, asphyxia

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Interventions

Intermittent Phototherapy. Babies who fulfil inclusion criteria will be selected into the study. Baseline serum bilirubin will be taken. They will undergo phototherapy for 10 hours and phototherapy wi

Intermittent Phototherapy. Babies who fulfil inclusion criteria will be selected into the study. Baseline serum bilirubin will be taken. They will undergo phototherapy for 10 hours and phototherapy will stop. After 6 hours without phototherapy, venous blood gas will be taken to see the bilirubin level as to prevent rebound jaundice. If the level requires phototherapy, we will restart the phototherapy and withdraw them from study to proceed with standard treatment. If they do not require phototherapy, another serum bilirubin will be taken at 24 hours of study. If they require another phototherapy, it is considered treatment failure. We will restart the phototherapy and proceed with standard treatment. The level that used to decide babies requiring phototherapy will be based on their age and risk following Malaysia Paediatric Protocol page 139. The phototherapy machine used is the same for both groups which is Babyblue LED Phototherapy Unit. It consists of 8 LED lights at the top chamber each delivering 25 - 35 µW/cm²/nm. To ensure adherence to the intervention, we will place baby in a cot and place them under phototherapy. The nursing time is same for all babies, this is to minimize interruption of treatment. Medical Officer and nurses will participate in this intervention including starting phototherapy, blood taking and nursing care of the patient,


Locations(1)

Malaysia

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