RecruitingACTRN12624001351505

Lactation Intensity and reduction in the prevalence of metabolic syndrome after a maternal complication of pregnancy: an observational cohort analysis

Lactation Intensity and reduction in the prevalence of metabolic syndrome after a maternal complication of pregnancy: an observational cohort analysis in women with a previous pregnancy complication.


Sponsor

University of Adelaide

Enrollment

250 participants

Start Date

Sep 1, 2023

Study Type

Observational

Conditions

Summary

Major pregnancy complications such as preeclampsia and gestational diabetes mellitus are associated with development of type II diabetes mellitus and coronary heart disease, which are becoming ever more prevalent in young women. Despite clinical recommendations to optimise cardiovascular disease (CVD) risk factors after a complication of pregnancy, tailored lifestyle programs have poor adherence and are not suited to the lifestyle of a mother during the early postpartum period. Breastfeeding (lactation) is associated with a reduction in hypertension and diabetes later in life, however there has not been a direct focus on elucidating how breastfeeding affects certain components of cardiometabolic health in women with a previous pregnancy complication within the early postpartum period. We hypothesize that those who have a higher lactation intensity over 6 months postpartum (>=0.8 intensity score) will have a lower risk of metabolic syndrome at 6 months postpartum following a major pregnancy complication. This project aims to determine if lactation intensity is associated with a reduction in the rate of metabolic syndrome at 6 months postpartum in women with a maternal complication of pregnancy.


Eligibility

Sex: FemalesMin Age: 18 YearssMax Age: 45 Yearss

Plain Language Summary

Simplified for easier understanding

Major pregnancy complications such as preeclampsia and gestational diabetes are not just health risks during pregnancy — they significantly raise a woman's chances of developing heart disease and type 2 diabetes in the years that follow. Breastfeeding is already known to offer some protection against these conditions later in life, but it is not fully understood whether the intensity of breastfeeding in the early postpartum period might reduce a woman's immediate risk of metabolic syndrome (a cluster of conditions including high blood pressure, high blood sugar, and abnormal cholesterol). This observational study is following women who are referred to a postpartum cardiovascular preventive clinic at 6 months after a complicated pregnancy. Researchers will measure whether women who breastfed at higher intensity (more frequently, for longer) over those 6 months have lower rates of metabolic syndrome compared to those who breastfed less or not at all. You may be eligible if you are 18 to 45 years old, have had a recent pregnancy complication (such as preeclampsia, gestational diabetes requiring medication, preterm birth before 35 weeks, a small baby, or placental abruption), and have been referred to a postpartum preventive care clinic. The study is observational — there is no change to your medical care.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

Eligible women who are referred to COFFEE (Cardiovascular Assessment After Obstetric Complications: Follow-Up For Education and Evaluation) clinic are included in this study. COFFEE clinic is a postpa

Eligible women who are referred to COFFEE (Cardiovascular Assessment After Obstetric Complications: Follow-Up For Education and Evaluation) clinic are included in this study. COFFEE clinic is a postpartum cardiovascular preventative service at the Lyell McEwin Hospital for women with previous complications of pregnancy. They are routinely assessed by a cardiac nurse practitioner at 6 months, 18 months and 5 years post-pregnancy for cardiovascular disease risk and primary prevention through lifestyle modification. Women at the time of their antenatal discharge will be contacted by the researcher either at time of discharge or within 5 weeks of discharge via telephone to participate in the study. Upon informed consent and enrollment to the study, participants will be asked to complete short, online questionnaires once a month on breastfeeding difficulties, and infant feeding patterns. They will complete 1 questionnaire a month for the period of 6 months. Data from their COFFEE clinic postpartum appointment at 6 months will be collected to assess cardio-metabolic risk factors including weight, blood pressure and biochemical markers.


Locations(1)

Lyell McEwin Hospital - Elizabeth Vale

SA, Australia

View Full Details on ANZCTR

For the most up-to-date information, visit the official listing.

Visit

ACTRN12624001351505