RecruitingACTRN12624001364561

EIT - Electrical impedance tomography assessment of lung homogeneity in infants undergoing inguinal hernia surgery; a prospective cohort study

Electrical impedance tomography assessment of lung homogeneity in infants undergoing inguinal hernia surgery; a prospective cohort study

Sponsor

Southern Adelaide Local Health Network

Enrollment

90 participants

Start Date

Dec 9, 2024

Study Type

Observational

Conditions

lung function during surgery inguinal hernia surgery

Summary

This study will use EIT to define the patterns of tidal ventilation within the chest in infants undergoing inguinal hernia surgery with four different anaesthetic types, two where they are spontaneously breathing, and two where they are having a general anaesthetic with either spontaneous ventilation with laryngeal mask airway or mechanical ventilation. This study will determine whether mechanical ventilation during general anaesthesia increases the risk of lung inhomogeneity in neonates and small infants. We also hope to determine if there is a correlation between the degree of lung inhomogeneity and the four types of anaesthetic techniques.

Eligibility

Sex: Both males and femalesMax Age: 64 Weekss

Plain Language Summary

Simplified for easier understanding

When young babies and infants have surgery under general anaesthetic, there are several different ways to manage their breathing — including allowing them to breathe on their own, or using a machine to breathe for them. It is not yet fully understood whether mechanical ventilation during infant surgery affects the uniformity of air distribution in the small lungs, which could potentially contribute to breathing complications after surgery. This study uses a technology called electrical impedance tomography (EIT) — a safe, non-invasive monitor that uses gentle electrical signals to create a real-time map of air movement inside the chest — to observe lung ventilation patterns in infants during inguinal hernia surgery. Four different types of anaesthetic and breathing management will be compared. Your infant may be eligible if they are less than 64 weeks post-menstrual age (counting from conception, not birth), are already scheduled to have inguinal hernia surgery, and the anaesthetic team has already decided on the breathing management approach. Infants who are on a breathing machine immediately before surgery or whose parents object to participation are not eligible.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

This study will use EIT (Electrical Impedance Topography) to define the patterns of tidal ventilation within the chest in infants undergoing inguinal hernia surgery with four different anaesthetic types, 1. spinal 2. caudal, sedation and high flow nasal oxygen 3. general anaesthesia with a supraglottic airway 4. general anesthesia with mechanical ventilation via an endotracheal tube. EIT is a non-invasive, radiation-free monitoring tool that allows real-time continuous imaging of ventilation at the bedside, measuring the impedance of the thorax through a belt placed around patient's chest. The belt will be placed on the patient by a member of the research team preoperatively. Five measurements will be taken, 1. preoperative baseline recording 2. after the commencement of anaesthesia just prior to knife to skin 3. at the end of surgical procedure prior to end anaesthesia (i.e when dressings being applied) 4. within 10 minutes from arrival to recovery/intensive care unit 5. just before discharge from recovery ward (or two hours post operatively if discharged directly from theatre to Neonatal Intensive Care/ Special Care Unit). The EIT device is not part of usual monitoring of infants in this setting and is being specifically utilised for this study to assess ventilation patterns.

Locations(1)

SA,VIC, Australia

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ACTRN12624001364561