RecruitingACTRN12624001424594

Role of Laparoscopic Uterine Artery Clipping in Refractory Abnormal Uterine Bleeding Related to Benign Causes

Role of Laparoscopic Uterine Artery Clipping in Refractory Abnormal Uterine Bleeding Related to Benign Causes in Women Age 35-55 (A Prospective Intervention study)


Sponsor

Maternity and children hospital faculty of medicine Minia University

Enrollment

100 participants

Start Date

May 10, 2025

Study Type

Interventional

Conditions

Summary

cases suffering from abnormal uterine bleeding due to benign causes will counseled for laparoscopic uterine artery clipping to assess the role of laparoscopic uterine artery clipping in management of refractory abnormal uterine bleeding related to benign causes and assess the ability of uterine artery clipping to control bleeding and avoidance of hysterectomy.


Eligibility

Sex: FemalesMin Age: 35 YearssMax Age: 55 Yearss

Plain Language Summary

Simplified for easier understanding

Abnormal uterine bleeding — heavy, irregular, or prolonged periods — is a common and distressing condition that can be caused by a range of benign (non-cancerous) conditions such as fibroids, adenomyosis, or endometriosis. When medications and hormonal treatments have not worked, many women are offered a hysterectomy (surgical removal of the uterus), but some prefer to explore uterus-preserving alternatives. This study is investigating a laparoscopic (keyhole) surgical procedure called uterine artery clipping, which works by reducing blood supply to the uterus to control abnormal bleeding. The goal is to evaluate whether this technique can effectively control bleeding and help women avoid a hysterectomy. It is a minimally invasive approach that may offer a meaningful option for women who want to keep their uterus. You may be eligible if you are a woman aged 35 to 55 years with abnormal uterine bleeding that has not responded to medical or hormonal treatments, have a benign gynaecological condition, prefer not to have a hysterectomy, and have a uterus no larger than the equivalent of a 16-week pregnancy. Women with suspected gynaecological cancer or those hoping to become pregnant in future are not eligible for this study.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

laparoscopic uterine artery ligation in cases of irregular uterine bleeding due to benign causes .The patient is placed in low lithotomy position using Allen stirrups. After establishment of pneumoper

laparoscopic uterine artery ligation in cases of irregular uterine bleeding due to benign causes .The patient is placed in low lithotomy position using Allen stirrups. After establishment of pneumoperitoneum and introduction of the first optic trocar through the umbilicus , the patient is put in Trendelenburg position of approximately 25 degrees. Maximal intrabdominal pressure is set to 12–13 mmHg. Two ancillary 5-mm trocars are inserted in each iliac fossa under direct vision lateral to the inferior epigastric vessels and one ancillary 10–12 mm trocar is inserted in the suprapubic area. Scissors, bipolar overhold. A uterine manipulator will be introduced, and laparoscopy will be performed using a 10-mm 0-degree laparoscope inserted using the open technique through an umbilical incision to primary port. Using monopolar diathermy (90 W cutting current and 60 W coagulation) with micro scissors and graspers, the peritoneum of the anterior leaf of the right broad ligament, between the round ligament and the infundibulopelvic ligament, will be incised. Ask the assistant to pull the infudibulopelvic ligament medially in more cephalic position to open the space. Extend the incision cephalic till the level of sacral promontory (the bifurcation of two common iliac arteries). Then gentle sweeping between external iliac artery towards the infundibulopelvic ligament to expose the ureter. the ureter which is the first key once seen, by gentle sweeping technique open the lateral pararectal space (dissection parallel to the ureter by one grasper and medialization of ureter by the other). Once the lateral pararectal space is opened, you will be able to see the internal iliac artery, just follow the direction and dissect over the obliterated umbilical artery which is the second key. Then grasp the obliterated umbilical artery and pull it up while asking the assistant to keep the space opened. This pulling technique will allow to see the vascular tree of the pelvis with clear vision of the uterine artery which is the first branch of anterior division of internal iliac artery which cross the lateral pararectal space from lateral to medial crossing above the ureter (water under bridge) and take care there may be a branch from the internal iliac cross the space also but passing to the ureter not above which is the ureteric branch. As the uterine artery still covered by fascia and for more safe clipping, dissect the medial Para vesical space above the uterine artery .so, you can clearly see the uterine artery which is the border between lateral pararectal and medial Para vesical space. You can now grasp uterine artery itself, dissect the artery from fascia below to avoid injury of the deep uterine vein, uterine artery will be isolated and permanently occluded with Liga clips Yasargil vascular clips and then coagulated. The procedure will be then repeated on the left side. The investigator is the surgeon . It will be done once in the setting The procedure will be done in the minimally invasive unit in department of Obstetrics and Gynecology. The approximate duration of the procedure is 45 - 55 minutes . counseling of patient about the details of procedure and postoperative follow up


Locations(1)

Minia city, Egypt

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ACTRN12624001424594