Assessment of the Effects of Nebulised Dexmedetomidine for Premedication on Inflammatory and Oxidative Stress Response in Children Undergoing Tonsillotomy and Adenoidectomy: A Pilot Study

This prospective randomized clinical trial was designed to asses the effect of inhaled dexmedetomidine in premedication on oxidative and inflammatory stress in children who underwent tonsillectomy and adenoidectomy. Inclusion criteria were: children 4-13 age, ASA I-II group, scheduled for tonsillectomy and adenoidectomy under general anesthesia, We hypothesized that nebulized dexmedetomidine reduces oxidative and inflammatory stress, does not affect hemodynamics and respiratory function, induces sedation and anesthesia, and reduces the consumption of opioids and analgesics. Primary outcomes were markers of oxydative and inflammatrory stress, The secondary outcomes were to examine the difference between groups caused by inhaled dexmedetomidine in the following secondary outcome variables: degree of sedation, BIS values, hemodynamics, respiratory function, analgesic consumption, frequency of complications, delirium score, pain score.