Are the postural orthostatic tachycardia syndrome diagnostic criteria limiting? Defining and comparing patient reported outcomes of an Australian cohort with postural symptoms without tachycardia
University of Adelaide
500 participants
Oct 28, 2024
Observational
Conditions
Summary
Postural orthostatic tachycardia syndrome (POTS) is a multisystem, autonomic disorder that culminates in extensive morbidity for those affected. POTS is currently diagnosed on the basis of strict heart rate response to a standing test in addition to the presence of orthostatic symptoms for greater than 3 months unexplained by another condition. However, the heart rate criterion is confounded by multiple factors and has not previously been well validated to correlate with symptoms. Additionally, little is known about whether individuals with postural symptoms without tachycardia (PSWT) have similar symptom burden and health related quality of life impairment to those with POTS. As such, we will explore the symptom burden of PSWT patients and compare this to a POTS cohort.
Eligibility
Inclusion Criteria4
- years old or older
- Understand and willing to sign the informed consent document
- The diagnostic evaluation must include, at a minimum, a medical history, physical
- examination, standing test/tilt table test, ECG, echocardiogram, Holter monitor
Exclusion Criteria3
- Non-consent for use of de-identified data in research
- Non-English speaker [or those who are unable to complete patient reported outcome measure surveys in English]
- Inability to provide consent due to vulnerable states or young age.
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Interventions
Study of patients with postural symptoms without tachycardia (PSWT) to evaluate symptom burden and health related quality of life by sequential patient reported outcome surveys (PROMS) which include treatment approach. The initial surveys will be gathered from medical data with the single timepoint follow up survey gathered prospectively beyond 10 months from initial review via email. PSWT patients are those with symptoms that have undergone a postural orthostatic tachycardia syndrome (POTS) work-up including ECG/ holter and tilt table test but, have not met the heart rate criteria (an increase >30 beats per minute within 10 minutes of standing).
Locations(1)
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ACTRN12625000058471