The effects of FloraSMART on gastrointestinal symptoms and health in older adults
Randomised controlled trial assessing the effects of FloraSMART A17 blend on gastrointestinal symptoms and health in older adults
Murdoch University
60 participants
Jan 26, 2026
Interventional
Conditions
Summary
The composition, diversity, and function of gut bacteria collectively referred to as the gut microbiome undergo notable changes with ageing. These changes can have significant impacts on overall health. For example, ageing is associated with an increased abundance of potentially harmful bacteria, such as Enterobacteriaceae, while certain beneficial bacteria such as Bifidobacterium often decline. These shifts can contribute to chronic low-grade inflammation and adverse health outcomes. The gut microbiome can be influenced through the use of supplements called prebiotics, probiotics and postbiotics. Multiple health benefits have been reported in response to supplementation with postbiotics in adults, however, most of the existing work has been done in assessing the health benefits in young adults, with very few studies specifically targeting older adults. The aim of this study is to identify whether supplementation with FloraSMART A17 blend reduces gastrointestinal symptoms and improves quality of life in older adults.
Eligibility
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Interventions
One capsule (20 mg) of FloraSMART A17 blend postbiotic (includes 17 mg of the tyndallized bacteria; Lactobacillus casei subsp. casei 327; Lactobacillus paracasei K71; Enterococcus faecalis EC-12; Bifidobacterium longum BR-108) sweet potato starch, tapioca starch. consumed at the same time each day for 6 weeks. Participants will be contacted each fortnight to record whether they have missed any doses or altered timing of the dose. Participants will visit the Murdoch University Physiology lab following 6 weeks of supplementation, during which they will be asked to return the bottle containing the supplements. The number of supplements remaining will be counted to determine compliance to the supplementation schedule. Participants who consume 80% or more of the study product will be considered adherent and included in the per-protocol analysis.
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ACTRN12625000813482