RecruitingACTRN12625000813482

The effects of FloraSMART on gastrointestinal symptoms and health in older adults

Randomised controlled trial assessing the effects of FloraSMART A17 blend on gastrointestinal symptoms and health in older adults


Sponsor

Murdoch University

Enrollment

60 participants

Start Date

Jan 26, 2026

Study Type

Interventional

Conditions

Summary

The composition, diversity, and function of gut bacteria collectively referred to as the gut microbiome undergo notable changes with ageing. These changes can have significant impacts on overall health. For example, ageing is associated with an increased abundance of potentially harmful bacteria, such as Enterobacteriaceae, while certain beneficial bacteria such as Bifidobacterium often decline. These shifts can contribute to chronic low-grade inflammation and adverse health outcomes. The gut microbiome can be influenced through the use of supplements called prebiotics, probiotics and postbiotics. Multiple health benefits have been reported in response to supplementation with postbiotics in adults, however, most of the existing work has been done in assessing the health benefits in young adults, with very few studies specifically targeting older adults. The aim of this study is to identify whether supplementation with FloraSMART A17 blend reduces gastrointestinal symptoms and improves quality of life in older adults.


Eligibility

Sex: Both males and femalesMin Age: 60 YearssMax Age: 80 Yearss

Plain Language Summary

Simplified for easier understanding

As we get older, the trillions of bacteria living in our gut — our microbiome — change in ways that can affect our health. Beneficial bacteria tend to decline while potentially harmful bacteria increase, contributing to gut discomfort and inflammation. Postbiotics are health-supporting compounds produced by or derived from beneficial bacteria, and they have shown promise in improving gut health in younger adults, but very little research has focused on older people. This study is testing whether a specific postbiotic supplement called FloraSMART A17 can reduce gut symptoms and improve quality of life in adults aged 60 to 80. Participants will take the supplement or a placebo for a set period and complete questionnaires about their digestive health and wellbeing. You may be eligible if you are aged 60 to 80, live independently in the community, and are generally well. You would not be eligible if you take three or more prescription medications, recently had antibiotics or a major procedure, have a serious gut condition, or are already taking probiotic or prebiotic supplements.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

One capsule (20 mg) of FloraSMART A17 blend postbiotic (includes 17 mg of the tyndallized bacteria; Lactobacillus casei subsp. casei 327; Lactobacillus paracasei K71; Enterococcus faecalis EC-12; Bifi

One capsule (20 mg) of FloraSMART A17 blend postbiotic (includes 17 mg of the tyndallized bacteria; Lactobacillus casei subsp. casei 327; Lactobacillus paracasei K71; Enterococcus faecalis EC-12; Bifidobacterium longum BR-108) sweet potato starch, tapioca starch. consumed at the same time each day for 6 weeks. Participants will be contacted each fortnight to record whether they have missed any doses or altered timing of the dose. Participants will visit the Murdoch University Physiology lab following 6 weeks of supplementation, during which they will be asked to return the bottle containing the supplements. The number of supplements remaining will be counted to determine compliance to the supplementation schedule. Participants who consume 80% or more of the study product will be considered adherent and included in the per-protocol analysis.


Locations(1)

WA, Australia

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ACTRN12625000813482