RecruitingPhase 3Phase 4ACTRN12625001236482

Comparative Efficacy of 70% Tricholoacetic acid versus cryotherapy in treatment of Xanthelasma palpebrum

Comparative Efficacy of 70% Tricholoacetic acid versus cryotherapy in treatment of Xanthelasma palpebrum in patients 20 years or older

Sponsor

Pakistan naval ship Shifa hospital, Karachi

Enrollment

60 participants

Start Date

Oct 6, 2025

Study Type

Interventional

Conditions

Xanthelasma palpaberum

Summary

A comparative study of 70% TCA with cryotherapy in xanthelasma palpebrum will be conducted at Dermatology out-patient department, PNS Shifa hospital Karachi after fulfilling the inclusion and exclusion criteria. After the informed written consent and permission from hospital’s ethics review committee, 30 patients will be divided in Group A & B. Patients in both the groups will receive treatment for 6 weeks and data from patient will be collected through a proforma on first visit and follow-ups. we hypothesise that trichloroacetic acid (TCA) will be more effective than freezing treatment at removing yellowish patches around the eyes (xanthelasma palpebrum).

Eligibility

Sex: Both males and femalesMin Age: 20 YearssMax Age: 60 Yearss

Plain Language Summary

Simplified for easier understanding

Xanthelasma palpebrum is a condition where yellowish, cholesterol-rich patches appear on or around the eyelids. While harmless, many people find them cosmetically distressing and want them removed. There are several ways to treat these patches, but it is not always clear which approach works best. This study is directly comparing two common methods: applying 70% trichloroacetic acid (a chemical that removes the tissue) versus cryotherapy (freezing the tissue with liquid nitrogen). Thirty participants will be divided into two groups and treated over six weeks, with the results assessed and compared to determine which method more effectively clears the patches. You may be eligible if you are aged 20 to 60, have xanthelasma patches on your eyelids (one or both eyes) that are between 0.5 and 1 cm in size, and have not received any treatment for them in the past six months. People with known sensitivity to TCA or liquid nitrogen, immune suppression, significant mental health conditions, or who are pregnant or breastfeeding are not eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients will be divided in two groups. Group-A will receive single session of 70% Trichloroacetic acid (TCA) topical application with blunt end of tooth pick( quantity enough to wet the tooth pick end but not dripping off from it) . It will be performed by the prime researcher. Follow-up will be done at 2, 4, and 6 weeks. Treatment will be labeled as effective if complete disappearance of lesion of Xanthelasma palpebrarum(XP). Side effects of the procedures will be assessed at follow up including hypopigmentation, hyperpigmentation and scaring. Demographic data such as age, gender, residence, socioeconomic status and education level of the patients will be recorded through pre designed proforma.

Locations(1)

Sindh, Pakistan

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ACTRN12625001236482