RecruitingPhase 2Phase 3ACTRN12625001306404

Comparing the therapeutic efficacy of oral minoxidil and oral finasteride in androgenic alopecia in males


Sponsor

Pakistan naval ship Shifa hospital, Karachi

Enrollment

62 participants

Start Date

Nov 3, 2025

Study Type

Interventional

Conditions

Summary

A comparative study of oral minoxidil 1.25 mg daily with oral finasteride 1 mg on alternate days in androgenic alopecia, will be conducted at Dermatology out-patient department, PNS Shifa hospital Karachi after fulfilling the inclusion and exclusion criteria. After the informed written consent and permission from hospital’s ethics review committee, 62 patients will be divided in Group A & B. Patients in both the groups will receive treatment for 6 months and data from patient will be collected through a proforma on first visit and follow-ups', etc. The study aims to compare the effectiveness of two medications, oral minoxidil and oral finasteride, in treating androgenic alopecia (male pattern baldness).


Eligibility

Sex: MalesMin Age: 18 YearssMax Age: 45 Yearss

Plain Language Summary

Simplified for easier understanding

Male pattern baldness (androgenic alopecia) is extremely common and can significantly affect self-esteem and wellbeing. It is caused by the effect of androgens (male hormones) on hair follicles over time. Two medications are commonly used to slow hair loss or promote regrowth: finasteride, which works by blocking the hormone signal, and minoxidil, which improves blood flow to hair follicles. Both are now available in oral tablet form, making them more convenient than topical treatments. This study is comparing the effectiveness of oral minoxidil (1.25 mg daily) versus oral finasteride (1 mg on alternate days) in men with early-to-moderate male pattern hair loss, over a six-month treatment period. Hair loss severity will be assessed using a standard photographic scale called the Hamilton-Norwood scale. You may be eligible if you are a male aged 18 to 45 with early-to-moderate androgenic alopecia (Hamilton-Norwood Stage I to IV), in generally good health, and have not received any hair loss treatment in the last three months. Patients with liver or kidney problems, hypersensitivity to either medication, or who are taking immunosuppressive therapy would not be eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients will be randomized into two groups (Group A&B). Group A will receive oral minoxidil 1.25mg daily ( Tab Minoxidil 2.5mg will be split into 2 halves and each half will be taken daily). All the

Patients will be randomized into two groups (Group A&B). Group A will receive oral minoxidil 1.25mg daily ( Tab Minoxidil 2.5mg will be split into 2 halves and each half will be taken daily). All the patients will be provided with the same brand of medicine to minimize brand bias. All patients will asked to bring used tablet pack at every visit ( 1 visit per month) for adherence purposes.


Locations(1)

Sindh, Pakistan

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ACTRN12625001306404