RecruitingACTRN12625001437459

The Effectiveness of Retrolaminar and Modified Thoracolumbar Interfascial Plane Blocks in the Management of Opioid-Free Anesthesia in Lumbar Discectomy

Comparison of the Effects of Retrolaminar and Modified Thoracolumbar Interfascial Plane Blocks on Postoperative Pain and Recovery Under Opioid-Free Anesthesia Management in Patients Undergoing Lumbar Discectomy: A Prospective, Double-Blind Study


Sponsor

Onur KUCUK (Dokuz Eylül University)

Enrollment

70 participants

Start Date

Nov 20, 2025

Study Type

Interventional

Conditions

Summary

This randomized, controlled, prospective study aims to compare the effects of Retrolaminar Block and Modified Thoracolumbar Interfascial Plane (mTLIP) Block on postoperative recovery parameters in patients undergoing lumbar discectomy under opioid-free general anesthesia.All participants will receive standardized general anesthesia without intraoperative opioid use. Preoperative pain sensitivity will be assessed using the Pain Sensitivity Questionnaire (PSQ) and Visual Analog Scale (VAS). The study's primary outcomes include the time from sevoflurane discontinuation to the first response to verbal command and the time to discharge from the post-anesthesia care unit (PACU), defined as reaching an Aldrete score greater than or equal to 9. Secondary outcomes include tracheal extubation time, postoperative VAS scores at specified intervals (30 min, 2 h, 4 h, 8 h, 12 h, and 24 h), time to first rescue analgesic request, total 24-hour analgesic consumption, and the incidence of postoperative nausea and vomiting.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

Back surgery for a herniated disc — called a lumbar discectomy — can be very effective, but managing pain during and after the operation without relying on opioid painkillers is a growing priority in modern medicine. This study is comparing two nerve-blocking techniques that deliver local anaesthetic to the area around the spine, allowing patients to have surgery under general anaesthesia without needing opioids at all. The two techniques being compared are called Retrolaminar Block and Modified Thoracolumbar Interfascial Plane Block. Both involve injecting local anaesthetic near the spine before or during surgery. Researchers will measure how quickly patients wake up from anaesthesia, how long they stay in the recovery room, and how much pain they experience in the 24 hours following surgery. You may be eligible if you are aged 18 to 65, generally in good health, and are scheduled for a planned one- or two-level lumbar disc operation under general anaesthesia. People with a history of prior spine surgery, chronic pain requiring opioids, or pregnancy are not eligible. This research is part of an important movement toward safer, opioid-sparing pain management in surgery.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Group Retrolaminar Block (RLB): Participants in this group will receive an ultrasound-guided bilateral Retrolaminar Block (RLB) prior to the induction of general anaesthesia. The procedure involves t

Group Retrolaminar Block (RLB): Participants in this group will receive an ultrasound-guided bilateral Retrolaminar Block (RLB) prior to the induction of general anaesthesia. The procedure involves the injection of 18 mL %0.25 bupivakain, 2 mL (8 mg) deksametazon on each side into the retrolaminar space at the L3 vertebral level using an in-plane technique. The injection is performed under sterile conditions using a linear ultrasound probe to visualize the lamina and ensure correct needle placement. - Drug: 18 mL %0.25 bupivakain, 2 mL (8 mg) deksametazon; 20 mL per side - Mode of administration: Single-shot injection, ultrasound-guided - Timing: Applied once after general anesthesia induction and intubation. - Monitoring adherence: Procedure details and drug dosage are recorded in patient medical records and anaesthesia charts.


Locations(1)

Izmir, Turkey

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