ClinicalTrialsFinder
RecruitingPhase 3Phase 4ACTRN12626000419369

Comparative efficacy of cryotherapy combined with trichloroacetic acid versus cryotherapy alone in treatment of plantar warts

Comparative efficacy of cryotherapy combined with trichloroacetic acid versus cryotherapy alone in treatment of plantar warts in children and Adults

Sponsor

Pakistan Naval Ship Shifa Hospital Karachi

Enrollment

50 participants

Start Date

Apr 2, 2026

Study Type

Interventional

Conditions

Plantar warts

Summary

A comparative study of 80% TCA with cryotherapy versus cryotherapy alone in plantar warts will be conducted at Dermatology out-patient department , PNS Shifa hospital Karachi after fullfilling the inclusion and exclusion criteria. After the informed written consent and permission from hospital's ethics review committee ,50 patients will be divided in Group A and Group B. Patients in both group will receive treatment till clearance of the plantar warts and data from patient will be collected through a porforma on first visit and follow-ups. We hypothesize that combination therapy using trichloroacetic acid (TCA) with cryotherapy is more effective than cryotherapy alone in the treatment and removal of warts.

Eligibility

Sex: Both males and femalesMin Age: 12 YearssMax Age: 60 Yearss

Inclusion Criteria4

  • Age 12 years and above , both genders.
  • Clinically diagnosed plantar warts confirmed by paring to demonstrate thrombosed capillaries.
  • Lesions 5 or more in number or mosaic plaques less than or equal to 4 cm in diameter.
  • Willingness to provide informed consent and adhere to follow-up.

Exclusion Criteria5

  • Immunocompromised patients (HIV, systemic steroid or chemotherapy use).
  • Peripheral vascular disease, diabetic foot, or neuropathy.
  • Pregnancy or lactation.
  • Local infection, ulceration, or recent treatment with TCA/cryotherapy (within 4 weeks).
  • Allergy to TCA or inability to tolerate cryotherapy.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

Patients will be divided in two groups. In Group A, cryotherapy will be performed by the investigator using liquid nitrogen applied via spray or cotton-tipped applicator for 10–15 seconds in two free

Patients will be divided in two groups. In Group A, cryotherapy will be performed by the investigator using liquid nitrogen applied via spray or cotton-tipped applicator for 10–15 seconds in two freeze–thaw cycles at 2-week intervals for up to six sessions or until clearance.

Locations(1)

Sindh, Pakistan

View Full Details on ANZCTR

For the most up-to-date information, visit the official listing.

Visit

ACTRN12626000419369