Examining the neuromodulatory effects of cannabidiol in healthy adults
Examining the neuromodulatory effects of cannabidiol in healthy adults: A randomised, double-blind, placebo-controlled, cross-over trial
Deakin University
40 participants
Jun 1, 2026
Interventional
Conditions
Summary
This project will be the first to comprehensively test the hypothesis that oral administration of cannabidiol (CBD) oil modulates brain excitation-inhibition (E-I) using a range of electrophysiological measures (aperiodic activity, gamma band oscillatory activity, mismatch negativity) using electroencephalography (EEG) in neurotypical adults. To that end, we will conduct a randomised, double-blind, placebo-controlled, crossover trial to examine the effect of acute dose 600mg CBD oil on EEG-derived measures of brain E-I.
Eligibility
Inclusion Criteria7
- Age 18-40 years
- Male or female
- Fluent in written and spoken English
- Normal or corrected-to-normal vision
- Normal hearing
- No intellectual disability
- Willing to undergo urine and blood sample collection
Exclusion Criteria6
- Known hypersensitivity to CBD, THC, cannabis or excipients used in product manufacture (MCT oil)
- Medicinal cannabis (on prescription) or illicit cannabis use (including unregulated CBD products) in the past 6 months
- Pregnant, breastfeeding or planning to become pregnant during the trial
- Current psychiatric, developmental, substance use, genetic, and neurological conditions
- Intellectual disability
- Currently taking psychoactive medications (e.g., benzodiazepines)
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Interventions
- 600mg cannabidiol (CBD) suspended in 6ml of medium-chain triglyceride (MCT) oil plus flavouring. - Single dose, administered oralorally (oil held under tongue for 1 minute). - Adherence will be monitored by trial staff observing participants hold the oil in their mouth for 1 minute (timed by trial staff) before swallowing. - 2-week washout between active and placebo interventions.
Locations(1)
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ACTRN12626000609358