MRS Measurement of Glutamate and GABA Metabolism in Brain

Exclusion Criteria11

• Any current Axis 1 diagnosis
• Clinically significant laboratory abnormalities
• Positive HIV test
• Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
• History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
• Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
• Serious medical illness as determined from H\&P or laboratory testing including Diabetes
• Inability to lie flat on camera bed for about two and a half hours
• Pregnant or breastfeeding
• Current substance use disorder based on DSM-5
• NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.