Identifying Genetic Causes of IC/BPS
Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Boston Children's Hospital
1,000 participants
Jan 15, 2006
OBSERVATIONAL
Conditions
Summary
Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, the investigators are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. The investigators are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.
Eligibility
Inclusion Criteria9
- Diagnosis of IC/BPS
- Males and females of any age
- Urinary frequency - more than 1X/hour, and/or
- Dysuria, and/or
- Pelvic, suprapubic, or abdominal pain - for 3 months or longer
- Nocturia
- Normal urinary stream (by history)
- No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
- First degree relative of someone with above symptoms
Exclusion Criteria5
- Major structural/anatomical urinary tract abnormalities by ultrasound
- Underlying inborn conditions affecting the urinary tract
- Surgery/chemotherapy affected pelvic area
- GI or GU cancers
- Severe Constipation in children only
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT00389142